At-Home Heart Rehab for Young Cancer Survivors at Heart Failure Risk
Tests an at-home heart exercise program in teen cancer survivors at risk of heart failure.
Plain-language title generated from the registry record
Registry title: At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
Key facts
- Where
- Los Angeles, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 0 and 21 years old?
Source: NCT06826534, who can take part
Where in United States
- Children's Hospital Los AngelesLos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Children's Hospital Los Angeles
- Trial code
- NCT06826534
- Record updated
- 14 February 2025
- Original description
The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer areRead full original descriptionShow less
At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are
* To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess barriers to compliance. * To explore which specific CORE resources are of most value to patients in creating sustainable healthy lifestyle modifications. * Hypothesis: Pediatric cancer survivors who implement exercise and dietary recommendations will demonstrate improvement in cardiovascular fitness and general wellness. A multidisciplinary team approach can facilitate adherence to a moderately rigorous exercise prescription, and thus enhance the health benefits of a CORE program at CHLA.
Participants will undergo cardiovascular studies and a quality-of-life survey prior to exercise intervention, and at the end of the 6-month study period.
Inclusion: Patients aged of 10-21 years at enrollment; Parent/legal guardian available for consent (if applicable), and patient available for assent and consent; History of anthracycline exposure +/- radiation; Currently in remission, with at least 6 months off chemotherapy; Able to perform CPET; Baseline CPET with VO2 <80% (at start of study, or CPET at CHLA after January 2020); Smartphone compatible with Fitbit (own or parent/legal guardian's); Ability to complete and send diary and Fitbit information on a weekly basis; Ability to participate in monthly virtual check-in visits; Baseline activity prior to intervention <30min/day, 2x/week.
Exclusion: No other primary medical diagnosis (e.g., Down Syndrome, Wolff-Parkinson-White Syndrome, congenital heart disease) or history of cardiothoracic surgery; Contraindication to moderate activity (>3 METs). Examples include history of malignant arrhythmias, exercise-induced syncope, severe symptoms of HF (NYHA IV, ACC/AHA Stage D); Unable to perform CPET, echocardiogram, EKG, or obtain laboratory studies; Inability to obtain consent/assent; Unable to accurately perform quality of life survey independently; Unable to perform mild activity for at least 0.5h/day and at least 2x/week; Unable to come to hospital for study visits at 0 and 6 months; Unable to complete study-related surveys; Unable to complete and send diary and Fitbit information on a weekly basis; Unable to check-in monthly on virtual platform; On beta blockade; Pregnancy.