Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Key facts
- Who runs it
- RAND
- Where
- Colton, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 4 Oct 2024
- Expected to end
- 31 Mar 2028
- Type of study
- Interventional, 6 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- SUN
- SUN + Telebridge
- ED-ITT
- ED-ITT + BHS
- Record updated
- 19 February 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Presented for ED care at ARMC
- Age 18 or older
- Probable OUD diagnosis
- Speak and understand English or Spanish
- Have capacity to give informed consent
- Provide a signed and dated informed consent form
Where in United States
- Arrowhead Regional Medical CenterColton, United StatesContact: Louis Tran, MDTaking people
About the trial
What the trial wants to find out
The ADAPT-ED study is a two-stage, sequential multiple assignment randomized trial (SMART) to inform the development of an adaptive intervention that is optimally effective in increasing long-term buprenorphine use for adults presenting to the ED with probable opioid use disorder (OUD).
The 6 groups in the trial
- SUN with no follow upExisting treatment, for comparison
In Arm A, participants are randomized to receive SUN-assisted treatment initiation and linkage to care. The patients are determined to be responders by 90 days and therefore receive no active follow up.
Treatment: SUN
- SUN followed by ED-ITTExisting treatment, for comparison
In Arm B, participants are randomized to receive SUN-assisted treatment initiation and linkage to care. The patients are determined to be non-responders within 90 days and are subsequently randomized into the ED-ITT condition to receive ongoing buprenorphine treatment by an ED-based interim treatment team.
Treatment: SUN and ED-ITT
- SUN followed by ED-ITT + BHSExisting treatment, for comparison
In Arm C, participants are randomized to receive SUN-assisted treatment initiation and linkage to care. The patients are determined to be non-responders within 90 days and are subsequently randomized into the ED-ITT + BHS condition to receive ongoing buprenorphine treatment by an ED-based interim treatment team augmented with a behavioral health consultant who will provide behavioral health support for up to 3 months.
Treatment: SUN and ED-ITT + BHS
- SUN + Telebridge with no follow upExisting treatment, for comparison
In Arm D, participants are randomized to receive SUN-assisted treatment initiation and linkage to care plus SUN-assisted immediate telehealth connection to an outpatient provider. The patients are determined to be responders by 90 days and therefore receive no active follow up.
Treatment: SUN + Telebridge
- SUN + Telebridge followed by ED-ITTExisting treatment, for comparison
In Arm E, participants are randomized to receive SUN-assisted treatment initiation and linkage to care plus SUN-assisted immediate telehealth connection to an outpatient provider. The patients are determined to be non-responders within 90 days and are subsequently randomized into the ED-ITT condition to receive ongoing buprenorphine treatment by an ED-based interim treatment team.
Treatment: SUN + Telebridge and ED-ITT
- SUN + Telebridge followed by ED-ITT + BHSExisting treatment, for comparison
In Arm F, participants are randomized to receive SUN-assisted treatment initiation and linkage to care plus SUN-assisted immediate telehealth connection to an outpatient provider. The patients are determined to be non-responders within 90 days and are subsequently randomized into the ED-ITT + BHS condition to receive ongoing buprenorphine treatment by an ED-based interim treatment team augmented with a behavioral health consultant who will provide behavioral health support for up to 3 months.
Treatment: SUN + Telebridge and ED-ITT + BHS
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 19 February 2026