NCT06828471Recruiting
Social Cognition Training in Individuals With Huntington's Disease
Social Cognition Training in Individuals With Huntington's Disease: A Feasibility Study
Source: ClinicalTrials.gov · Last updated 10 Dec 2025
Brief summary (registry, in English)
Individuals with Huntington's Disease have impaired social cognition, which is the domain of cognition that allows individuals to understand others' perspectives so that they can navigate interpersonal actions successfully (e.g., understanding someone may be sad based of their facial emotion or tone of voice and then responding in a sympathetic manner). Impaired social cognition is associated with impaired social functioning, poor psychological wellbeing and increased caregiver burden, which is known to be significant among those who care for individuals with Huntington's Disease. Computerized social cognition training has been shown to improve social cognition in individuals with schizophrenia, who, like individuals with Huntington's disease, have cognitive impairments. The investigators propose a pilot study of computerized social cognition training in individuals with Huntington's disease. This will be a feasibility study that aims to show that social cognition training in HD can be studied in preparation for a larger randomized controlled trial. The investigators hypothesize that social cognition training can improve social cognition, social functioning, and quality of life in individuals with Huntington's Disease and decrease caregiver burden among those who care for individuals with Huntington's Disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 11 Feb 2025
- Start date
- 15 Nov 2025
- Primary completion date
- 15 Dec 2027
- Lead sponsor
- Rush University Medical Center
- Diseases
- Huntington's disease
- NCT number
- NCT06828471
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 15 Nov 2025 to the primary completion date, 15 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any known neurological condition (other than Huntington's Disease).
- History of learning and/or intellectual disabilities
Other
- Currently actively involved in any other interventional trial (i.e. have begun the intervention) or within 4 weeks of completing the final assessments of an interventional trial.
- Currently regularly completing a computerized cognitive training intervention.
- Active suicidal ideation with some intent
- Inability to provide informed consent
- Active suicidal ideation with some intent
Who the study is looking for
- Diagnosed with Huntington's Disease based on genetic testing
- Must be between 18 and 65 years of age
- Native English speaker who is literate in English
- Stable psychotropic medication regimen for 4 weeks
- Must have a score of "somewhat easily" on all items in the CPQ-12
- MOCA \>18
- Completed 12 years of schooling
- Access to laptop or mobile device
- Willingness to come in person 6-12 weeks after first visit
- Lives with patient
- Must be between 18 and 65 years of age
- Native English speaker who is literate in English
- MOCA \>26
- Willingness to come in person within 6-12 weeks after first visit
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.