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Taking people in ChinaPhase 3

Tests TQC2731 injection in adults with hard-to-control severe asthma

Compares TQC2731 injection with placebo in adults whose severe asthma is poorly controlled.

Plain-language title generated from the registry record
Registry title: TQC2731 Clinical Trial for the Treatment of Severe Asthma With Injection

Key facts

Where
Anyang, Baotou, Beijing, Bozhou, Cangzhou, Changchun, Changsha, Chengdu, Chifeng, Dalian, Daqing, Enshi, Foshan, Gansu, Guangzhou, Guilin, Guiyang, Haikou, Harbin, Hefei, Heze, Hohhot, Huizhou, Jiaozuo, Jinan, Jincheng, Jinhua, Jining, Kunming, Lanzhou, Loudi, Lu'an, Luoyang, Nanchang, Nanjing, Ningbo, Panjin, Pingxiang, Qingdao, Qiqihar, Shanghai, Shenyang, Shihezi, Suining, Tai’an, Taiyuan, Taizhou, Tianjin, Tongling, Ürümqi, Weifang, Wenzhou, Wuhan, Wuxi, Xi'an, Xi’an, Xiamen, Xianyang, Xingtai, Xinxiang, Xuzhou, Yangquan, Yangzhou, Yantai, Yibin, Yinchuan, Yuyao, Zaozhuang, Zhangzhou, Zhengzhou, Zhenjiang, Zhongshan, Zhoukou, and Zibo, ChinaSee the 101 sites
Phase
Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Source: NCT06829784, who can take part

Where in China

  • The People's Hospital of AnyangAnyang, ChinaNot yet recruiting
  • Baotou Central HospitalBaotou, ChinaNot yet recruiting
  • The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyBaotou, ChinaNot yet recruiting
  • Beijing No.6 HospitalBeijing, ChinaNot yet recruiting
  • Peking University First HospitalBeijing, ChinaNot yet recruiting
  • The People's Hospital of BozhouBozhou, ChinaNot yet recruiting
  • Cangzhou Hospital of Integrated TCM-WM·HebeiCangzhou, ChinaNot yet recruiting
  • Jilin University Second HospitalChangchun, ChinaNot yet recruiting
  • The First Hospital of Jlin UniversityChangchun, ChinaNot yet recruiting
  • Changsha Central HospitalChangsha, ChinaNot yet recruiting
  • Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)Changsha, ChinaNot yet recruiting
  • The Second Xiangya Hospital of Central South UniversityChangsha, ChinaNot yet recruiting
  • Chengdu Fifth People's HospitalChengdu, ChinaNot yet recruiting
  • Sichuan Academy of Medical Sciences sichuan Provincial People's HospitalChengdu, ChinaNot yet recruiting
  • West China Hospital，Sichuan UniversityChengdu, ChinaNot yet recruiting
  • Chifeng Municipal HospitalChifeng, ChinaNot yet recruiting
  • Dalian Municipal Central HospitalDalian, ChinaNot yet recruiting
  • Da Qing Long Nan HospitalDaqing, ChinaNot yet recruiting
  • Enshi Tujia and Miao Autonomous Prefecture Central HospitalEnshi, ChinaNot yet recruiting
  • The Eighth Afliated Hospital of Southern Medical University The First people's Hospital of ShundeFoshan, ChinaNot yet recruiting
  • Gansu Provincial HospitalGansu, ChinaNot yet recruiting
  • Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou, ChinaNot yet recruiting
  • Guangzhou First People's HospitalGuangzhou, ChinaNot yet recruiting
  • The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, ChinaTaking people
  • Guilin People's HospitalGuilin, ChinaNot yet recruiting
  • The Affiliated Hospital of Medical UniversityGuilin, ChinaNot yet recruiting
  • Guizhou Provincial People's HospitalGuiyang, ChinaNot yet recruiting
  • The First Affiliated Hospital of Hainan Medical UniversityHaikou, ChinaNot yet recruiting
  • The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin, ChinaNot yet recruiting
  • Anhui Chest HoispitalHefei, ChinaNot yet recruiting
  • The First Affiliated Hospital of Anhui Medical UniversityHefei, ChinaNot yet recruiting
  • Heze Municipal HospitalHeze, ChinaNot yet recruiting
  • Inner Mongolia Autonomous Region People's HospitalHohhot, ChinaNot yet recruiting
  • The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot, ChinaNot yet recruiting
  • Third People's Hospital of HuizhouHuizhou, ChinaNot yet recruiting
  • The Second People's Hospital of Jiaozuo CityJiaozuo, ChinaNot yet recruiting
  • Central Hospital Affiliated to Shandong First Medical UniversityJinan, ChinaNot yet recruiting
  • Jincheng General HospitalJincheng, ChinaNot yet recruiting
  • Jinhua Municipal Central HospitalJinhua, ChinaNot yet recruiting
  • Affiliated Hospital of Jining Medical HospitalJining, ChinaNot yet recruiting
  • The First Affiliated of Kumming Medical UniversityKunming, ChinaNot yet recruiting
  • The First People's Hospital of Yunnan ProvinceKunming, ChinaNot yet recruiting
  • The First Hospital of Lanzhou UniversityLanzhou, ChinaNot yet recruiting
  • The Second Hospital & Clinical Medical School Lanzhou UniversityLanzhou, ChinaNot yet recruiting
  • Loudi Central HospitalLoudi, ChinaNot yet recruiting
  • Lu'an People's Hospital of Anhui ProvinceLu'an, ChinaNot yet recruiting
  • Luo Yang Dong Fang People's HospitalLuoyang, ChinaNot yet recruiting
  • The First Affiliated Hospital of NanChang UniversityNanchang, ChinaNot yet recruiting
  • Affiliated Hospital of Jiangsu UniversityNanjing, ChinaNot yet recruiting
  • The First Affiliated Hospital of Ningbo UniversityNingbo, ChinaNot yet recruiting
  • Genertec Liaoyou Gem Flower HospitalPanjin, ChinaNot yet recruiting
  • Pingxiang People's HospitalPingxiang, ChinaNot yet recruiting
  • The Affiliated Hospital of Qingdao UniversityQingdao, ChinaNot yet recruiting
  • The first hospital of QiqiharQiqihar, ChinaNot yet recruiting
  • Fudan University Affiliated Zhongshan HospitalShanghai, ChinaNot yet recruiting
  • Rui Jin Hospital Shanghai Jiaotong University School of MedicalShanghai, ChinaNot yet recruiting
  • Shanghai General HospitalShanghai, ChinaNot yet recruiting
  • Shanghai Pudong Hospital, Fudan University Affiliated Pudong Medical CenterShanghai, ChinaNot yet recruiting
  • Wusong Central Hospital, Baoshan District, ShanghaiShanghai, ChinaTaking people
  • People's Liberation Army North Theater General HospitalShenyang, ChinaNot yet recruiting
  • Shengjing Hospital affiliated to China Medical UniversityShenyang, ChinaNot yet recruiting
  • Shengjing Hospital Of China Medical UniversityShenyang, ChinaNot yet recruiting
  • The First Affiliated Hospital of Shihezi UniversityShihezi, ChinaNot yet recruiting
  • Suining Central HospitalSuining, ChinaNot yet recruiting
  • The Second Affiliated Hospital of Shandong First Medical UniversityTai’an, ChinaNot yet recruiting
  • Shanxi Bethune HospitalTaiyuan, ChinaNot yet recruiting
  • Taizhou Central Hospital(Taizhou University Hospital)Taizhou, ChinaNot yet recruiting
  • Tianjin 4th Center HospitalTianjin, ChinaNot yet recruiting
  • Tianjin Medical University General HospitalTianjin, ChinaNot yet recruiting
  • Tongling People's HospitalTongling, ChinaNot yet recruiting
  • First Affiliated Hospital of Xinjiang Medical UniversityÜrümqi, ChinaNot yet recruiting
  • People's Hospital of Xinjiang Uygur Autonomous RegionÜrümqi, ChinaNot yet recruiting
  • Weifang NO.2 People's HospitalWeifang, ChinaNot yet recruiting
  • The 2nd School of Medicine,WMU/The 2nd Affiliated Hospital and Yuying Children's Hospital of WMUWenzhou, ChinaNot yet recruiting
  • The Central Hospital of WuhanWuhan, ChinaNot yet recruiting
  • Wuxi Second People's HospitalWuxi, ChinaNot yet recruiting
  • The First Affiliated Hospital of Xi'an Medical UniversiXi'an, ChinaNot yet recruiting
  • The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an, ChinaNot yet recruiting
  • Xi'an International Medical Center HospitalXi'an, ChinaNot yet recruiting
  • Xi'an People's Hospital (Xi'an Fourth Hospital)Xi'an, ChinaNot yet recruiting
  • The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an, ChinaNot yet recruiting
  • The First Affiliated hospital of Xiamen UniversityXiamen, ChinaNot yet recruiting
  • No.215 Hospital of Shaanxi nuclear industryXianyang, ChinaNot yet recruiting
  • Xingtai People's HospitalXingtai, ChinaNot yet recruiting
  • Xinxiang Central HospitalXinxiang, ChinaNot yet recruiting
  • The affiliated hospital of xuzhou medical universityXuzhou, ChinaNot yet recruiting
  • Xuzhou Central HospitalXuzhou, ChinaNot yet recruiting
  • Yangquan Coal Industry(Group) General HospitalYangquan, ChinaNot yet recruiting
  • Northern Jiangsu People's HospitalYangzhou, ChinaNot yet recruiting
  • Yantai Yuhuangding HospitalYantai, ChinaNot yet recruiting
  • Yibin Second People's HospitalYibin, ChinaNot yet recruiting
  • The First People's Hospital of YinchuanYinchuan, ChinaNot yet recruiting
  • The People's Hospital of YuyaoYuyao, ChinaNot yet recruiting
  • Zaozhuang Municipal HospitalZaozhuang, ChinaNot yet recruiting
  • Zhangzhou Municipal Hospital of FujianZhangzhou, ChinaNot yet recruiting
  • Henan Provincial People's HospitalZhengzhou, ChinaNot yet recruiting
  • Zhengzhou Central HospitalZhengzhou, ChinaNot yet recruiting
  • Jiangsu University Affiliated HospitalZhenjiang, ChinaNot yet recruiting
  • Zhongshan City People's HospitalZhongshan, ChinaNot yet recruiting
  • Zhoukou Central HospitalZhoukou, ChinaNot yet recruiting
  • Zibo Central hospitalZibo, ChinaNot yet recruiting

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Trial code
NCT06829784
Record updated
19 August 2026
Original description
This study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial designed to evaluate the efficacy and safety of TQC2731 injection (420 mg Q4W) in adult subjects with inadequately controlled severe asthma. A total of 660 trial participants are expected to be enrolled, with trial participants randomized in a 1:1 ratio to receive either TQC2731 (420 mg Q4W) or placebo (Q4W) via subcutaneous (SC) administration.Read full original descriptionShow less

A Multicenter, Randomized, Double-blind, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of TQC2731 Injections in Patients With Poorly Controlled Severe Asthma

This study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial designed to evaluate the efficacy and safety of TQC2731 injection (420 mg Q4W) in adult subjects with inadequately controlled severe asthma. A total of 660 trial participants are expected to be enrolled, with trial participants randomized in a 1:1 ratio to receive either TQC2731 (420 mg Q4W) or placebo (Q4W) via subcutaneous (SC) administration.

Inclusion: Sign the informed consent form before the trial to fully understand the purpose, process and possible adverse reactions of the trial; Age 18 ~ 75 years old, gender is not limited; Documented physician diagnosis of asthma at least 12 months prior to Visit 1; Subjects who received high-dose Inhaled Corticosteroids (ICS) in asthma control medications prescribed by their physicians at least 6 months prior to Visit 1; There must be a record of receiving a stable total daily dose of ICS at least 3 months prior to visit 1; There must be a record of the use of other asthma control medications at a stable dose at least 3 months prior to visit 1; For subjects taking maintenance oral hormones, the dose of oral hormones is up to 10mg prednisone per day or 20mg every other day (or equivalent) and must be stable for at least 30 days prior to visit 1 and during treatment; Documented at least 2 asthma exacerbations in the 12 months prior to Visit 1 and no major asthma exacerbation events in the 1 month prior to signing informed.

Exclusion: Cancer history: Patients with basal cell carcinoma, skin localized squamous cell carcinoma, or cervical carcinoma in situ are eligible to be enrolled in this study if they had completed curative therapy for at least 12 months prior to visit 1. Patients with other malignancies who had completed curative treatment for at least 5 years prior to visit 1 could be enrolled in the study; Current smoker or smoking history ≥10 pack-years (former smokers with smoking history <10 pack-years had quit smoking less than 6 months before interview 1); Have a clinically significant lung disease other than asthma；; Pre-existing autoimmune disease; A history of known or suspected immunosuppression, including a history of invasive opportunistic infections; Any disease that has not been determined to be stable by the investigator；; Other factors determined by the investigator that subjects were not suitable to participate in the study.

ClinicalTrials.gov NCT06829784