Exercise Plus Weight Loss Surgery and Brain Inflammation in Obesity
Tests exercise combined with bariatric surgery in adults with obesity.
Plain-language title generated from the registry record
Registry title: Neurological Impact of Weight Reduction and Fitness Interventions
Key facts
- Where
- Royal Prince Alfred Hospital, AustraliaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06830252, who can take part
Where in Australia
- Charles Perkins Centre ClinicRoyal Prince Alfred Hospital, AustraliaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sydney
- Trial code
- NCT06830252
- Record updated
- 17 February 2025
- Original description
This study will test how significant weight loss through bariatric surgery, combined with a personalised exercise program, affects brain inflammation. Th investigators want to understand the connection between obesity-related body inflammation, metabolic issues, and brain inflammation and function.Read full original descriptionShow less
A Randomised Controlled Trial To Evaluate the Effects of Marked Weight Loss Combined With Exercise Training on Metabolic, Immunological, and Imaging Biomarkers of Systemic and Brain Inflammation in Participants Undergoing Bariatric Surgery
This study will test how significant weight loss through bariatric surgery, combined with a personalised exercise program, affects brain inflammation. Th investigators want to understand the connection between obesity-related body inflammation, metabolic issues, and brain inflammation and function.
Inclusion: 18-80 years of age; Eligible for bariatric surgery; Willingness to provide informed consent and willingness to participate and comply with the study requirements.
Exclusion: Non-MRI-compatible implanted devices or implants; Concurrent participation in any other interventional study; History or clinical manifestation of any other significant metabolic, hematologic, pulmonary, cardio- vascular, gastrointestinal, neurologic, immune, hepatic, renal, urologic, muscular, and joint disorders, or cancer that, in the opinion of the investigator, would make the candidate ineligible for the study. For example, significant joint pain could interfere with adherence to the exercise program; Have objectively assessed cognitive impairment as assessed by the Montreal Cognitive Assessment (MoCA) i.e., total score less than 26; Psychiatric or behavioural problems (history of drug and alcohol abuse, eating disorder); Unable to undertake MRI due to size restrictions i.e., shoulder width more than 70 cm; Inability to exercise via supine ergometer; Claustrophobia; Breastfeeding or pregnant women, or those intending to become pregnant before the scheduled end of the intervention; Unwilling to be assigned at random to the exercise or control intervention; Unwilling or unable to adhere to the rigors of the exercise intervention or evaluation schedule over the entire one-year period.