NCT06833944Recruiting
High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)
Unraveling the Potential of Physical Activity in the Treatment of Familial Hypercholesterolemia: Impact of Exercise on Cardiorespiratory Fitness, Atherosclerosis Progression, and Underlying Mechanisms
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects. The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 27 Jan 2025
- Start date
- 20 Feb 2025
- Primary completion date
- 28 Feb 2027
- Lead sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
- Diseases
- Familial hypercholesterolaemia
- NCT number
- NCT06833944
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 20 Feb 2025 to the primary completion date, 28 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of clinical CVD (ischemic heart disease, stroke, and/or peripheral arterial disease).
Other
- Inability to read, understand and sign the informed consent.
- Contraindications to exercise.
Who the study is looking for
- Individuals with a diagnosis of genetic FH.
- \> 18 years old.
- Minimum follow-up of 1 year in the Vascular Risk Clinic of the Virgen de las Nieves University Hospital (HUVN).
- Clinical and treatment stability.
- Non-pathological angio-TAC of coronary arteries in the 2 years prior to the study (for participants \>45 years old).
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Virgen de las Nieves University Hospital Coordinator of this site? Confirm its status | Granada | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.