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TerminatedNo phase

Effects of Yoghurt Consumption on Glucose Metabolism in Prediabetic Subjects

Key facts

Who runs it
Danone Global Research & Innovation Center
Where
France1 site in 1 countryChoose a country to see its sites
Trial code
Status
Terminated
People taking part
8 people enrolled
Started
16 Sept 2025
Ended
15 Oct 2025
Type of study
Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • Yoghurt
  • Milk
Record updated
12 January 2026
Why it stopped
The current operational setting is not sustainable and very unlikely to deliver the planned enrollment of 60 participants. Even with significant protocol amendments, these challenges would remain.

Who can take part

Age
18 years to 65 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 31 criteriaShow less

Who can take part

  • Signed ICF
  • Male/Female 18-65 years
  • BMI 25-35 kg/m2
  • FPG 100-125 mg/dL
  • At least one relative with T2DM
  • BW maintained (<3%)
  • Female postmenopausal or sterile or using contraceptive method
  • Ability to comply with study protocol form
  • Access to a refrigerator at home for study products storage
  • Ability to collect and store stool samples
  • Coverage by French health insurance
  • Agreement to be registered in the national database of subjects participating in clinical research
  • Ability to complete ePRO
  • FPG 100-125 mg/dL at randomisation visit

Who cannot take part

  • Diagnosis of T2DM, T1DM, or on antidiabetic medications
  • Medications or supplements affecting gut microbiota or causing hyperglycemia
  • Treatment interfering with BW and bariatric surgery
  • Recent surgery or general anesthesia
  • Liver, renal, cardiovascular, respiratory, endocrine, metabolic disorders, or iatrogenic immunodeficiency
  • Chronic gastro-intestinal disorders or recent use of laxatives
  • Allergy or intolerance to study product ingredients
  • Systemic antibiotic treatment
  • Donation/Loss of blood
  • Inability to comply with dietary restriction
  • Excessive consumption of alcohol
  • Smoker
  • Pregnancy, breast-feeding or change in contraceptive methods
  • Situation interfering with optimal participation
  • Participation in other clinical study
  • Living in the same home as another participant
  • Employees, family members of Danone

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The purpose of this study is to explore the effects of yoghurt consumption on glucose metabolism in prediabetic subjects.

The 2 groups in the trial

  • YoghurtTreatment being tested

    2% fat yoghurt. Subjects will consume two servings (125 g/serving) of the test product per day.

  • MilkPlacebo, for comparison

    2% fat cow's milk. Subjects will consume two servings (125 g/serving) of the control product per day.

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Randomised, Open Label, Controlled, Parallel-group Study to Explore the Effects of 24 Weeks Intake of Yoghurt on Glucose Metabolism in Subjects at High Risk of Type 2 Diabetes Mellitus
Record updated
12 January 2026