Comparing Two Levels of Sedation During Heart Rhythm Ablation Procedures
Compares deep sedation with conscious sedation in adults with atrial fibrillation undergoing catheter ablation.
Plain-language title generated from the registry record
Registry title: Deep Sedation in Catheter Ablation of Atrial Fibrillation
Key facts
- Where
- Dalian, Guangzhou, Hangzhou, Hefei, Nanchang, Nanjing, Ningbo, Qingdao, Shanghai, Suzhou, Taiyuan, and Tianjin, ChinaSee the 16 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with atrial fibrillation who are due to have a catheter ablation procedure. It compares deep sedation with conscious sedation.
- Age
- 18 to 75 years old
- Sex
- Men and women can both join
- Disease stage
- Atrial fibrillation that is paroxysmal, persistent or long-standing, and who can have a catheter ablation procedure
- Earlier treatment
- Cannot have had a catheter ablation for atrial fibrillation or an atrial septal defect repair before
Main reasons for not taking part
- Left atrial diameter of 55 mm or more, or a blood clot in the left atrium
- Stroke or transient ischemic attack in the last three months
- History suggesting sleep apnea, or cannot tolerate sedation
- BMI above 35 kg/㎡
- Pregnant or breastfeeding women
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06836999, who can take part
Where in China
- First Affiliated Hospital of Dalian Medical UniversityDalian, ChinaContact: Xiaomeng Yin, Ph.DNo longer taking part
- Guangdong Provincial People's HospitalGuangzhou, ChinaContact: Yumei XueNo longer taking part
- Nanfang HospitalGuangzhou, ChinaContact: Yuegang WangNo longer taking part
- Sir Rung Rung Shaw Hospital, Zhejiang University School Of MedicineHangzhou, ChinaContact: Sheng XiaNo longer taking part
- The Second Affiliated Hospital of Zhejiang UniversityHangzhou, ChinaContact: Yaping WangNo longer taking part
- Anhui Provincial HospitalHefei, ChinaContact: Hao SuNo longer taking part
- The First Affiliated Hospital of NanChang UniversityNanchang, ChinaContact: Ran YinNo longer taking part
- The Second Affiliated Hospital of Nanchang UniversityNanchang, ChinaContact: Qi ChenNo longer taking part
- Jiangsu Provincial HospitalNanjing, ChinaContact: Minglong ChenNo longer taking part
- The Affiliated Hospital Of Medical School Of Ningbo UniversityNingbo, ChinaContact: Huimin ChuNo longer taking part
- QingDao Municipal HospitalQingdao, ChinaContact: Bingong LiNo longer taking part
- Shanghai East HospitalShanghai, ChinaContact: Zhigang ZhangNo longer taking part
- The First Affiliated Hospital of Soochow UniversitySuzhou, ChinaContact: Tingbo JiangNo longer taking part
- Shanxi Cardiovascular HospitalTaiyuan, ChinaContact: Haixiong WangNo longer taking part
- Tianjin Chest HospitalTianjin, ChinaContact: Fengmin LuNo longer taking part
- Tianjin Medical University General HospitalTianjin, ChinaContact: Heng CaiNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- The First Affiliated Hospital of Dalian Medical University
- Trial code
- NCT06836999
- Record updated
- 4 March 2025
- Original description
The current practice of anesthesia for atrial fibrillation catheter ablation （CA） procedure is inconsistent, including general anesthesia, deep sedation, and conscious sedation.Due to the nature of deep sedation, it has been continuously gaining its position as one of the crucial components in standard practices of atrial fibrillation ablation during the last decade. Currently, a considerable number of procedures have been done using conscious sedation. Previous studies explored the benefits obtained from the employment of deep sedation in AF ablation procedures, mainly focused on pain reduction and intra-procedural safety. However, the benefits on long-term rhythmic outcomes, peri-procedural safety as well as benefits on procedural parameters and peri-procedural experiences from patients/ablators/lab staff have yet not to be thoroughly studied. We plan to conduct a prospective, multicenter, randomized, controlled trial to evaluate the benefits of deep sedation in catheter ablation of paroxysmal and persistent AF in multiple prospective, i.e., quantified intraprocedural patients / physicians / lab staffs / mapper clinical specialist experiences, and the procedure safety.Read full original descriptionShow less
Using Deep Sedation vs. Conscious Sedation in Catheter Ablation in Patients With Atrial Fibrillation: Intraprocedural Management and Outcome Evaluation
The current practice of anesthesia for atrial fibrillation catheter ablation （CA） procedure is inconsistent, including general anesthesia, deep sedation, and conscious sedation.Due to the nature of deep sedation, it has been continuously gaining its position as one of the crucial components in standard practices of atrial fibrillation ablation during the last decade. Currently, a considerable number of procedures have been done using conscious sedation. Previous studies explored the benefits obtained from the employment of deep sedation in AF ablation procedures, mainly focused on pain reduction and intra-procedural safety. However, the benefits on long-term rhythmic outcomes, peri-procedural safety as well as benefits on procedural parameters and peri-procedural experiences from patients/ablators/lab staff have yet not to be thoroughly studied. We plan to conduct a prospective, multicenter, randomized, controlled trial to evaluate the benefits of deep sedation in catheter ablation of paroxysmal and persistent AF in multiple prospective, i.e., quantified intraprocedural patients / physicians / lab staffs / mapper clinical specialist experiences, and the procedure safety.
Inclusion: ● Patients diagnosed with AF (paroxysmal, persistent, or long-standing) at 18-75 years old who are eligible for the CA procedure.
Exclusion: has received CA procedure for AF or atrial septal defect repair before enrollment; those who have participated in other clinical drug trials within 3 months prior to enrollment; left atrial diameter (LAD) ≥55 mm or thrombosis in the left atrium; a history of cerebrovascular disease within the last three months (including stroke and transient ischemic attack [TIA]); acute or severe systemic infection; those who are known to be allergic to any of the ingredients such as lidocaine, propofol, soybeans, peanuts, etc; eGFR<30mL/min/1.73㎡; Congenital heart disease, thyroid dysfunction, severe hepatic insufficiency (Child-Pugh classification B-C), severe coagulation dysfunction (international normalized ratio (INR) > 1.5 or partial activated prothrombin time (APTT) prolonged by ≥ 10 seconds, or plasma prothrombin time (PT) prolonged by ≥ 3 seconds, or fibrinogen (Fib) ≤ 1.5 g/L), or active bleeding; intolerant to sedation or with a history suggestive of sleep apnea; BMI > 35 kg/㎡; has contraindications to procedural sedation or refused to participate in this trial; pregnant women, breastfeeding women or women who plan to become pregnant during the study period, those who have a positive pregnancy test result during the screening period; life expectancy < 12 months; those who, in the judgment of the investigator, are not suitable for this clinical study (e.g., not in line with the treatment that the research participants the treatment, research participant compliance, etc.).