Enrolling by invitationNo phase

Rhythmic Sound Cues to Study Walking in Stroke and Parkinson Patients

Compares rhythmic sound stimulation with no stimulation in adults with stroke or Parkinson disease.

Key facts

Who runs it: YiCheng Zhu
Where: Beijing, ChinaSee the site
Trial code: NCT06837038
Registry title: Clinical Study of Rhythmic Auditory Stimulation for Gait Disorders
Status: Enrolling by invitation
People taking part: 60 people, planned
Started: 1 Dec 2024
Planned end: 31 Oct 2025
Type of study: Interventional, 2 groupsOne group gets a sham (pretend) treatment, for comparison.
Treatments tested: rhythmic auditory stimulation
No rhythm stimulation
Record updated: 20 February 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 50 to 80 with a walking problem after a stroke, Parkinson's disease or another parkinsonism syndrome. They test rhythmic sound cues to see if walking speed improves.

Age: 50 to 80 years
Sex: All sexes can join.
Disease stage: Stroke with weakness on one side (last stroke at least 6 months ago), Parkinson's disease at Hoehn-Yahr stage 2-4, or another parkinsonism syndrome. All must walk alone without a cane or walking aid and have a walking speed above 0.4 m/s and below 0.8 m/s.
Earlier treatment: People cannot be receiving any other rehabilitation treatment at present.

Main reasons for not taking part

Cannot cooperate with the movement tests
Uncontrolled high blood pressure
Heart attack within the past 3 months
Bone or joint problems that seriously affect walking, such as a leg fracture within 1 year
Other nervous system diseases that affect walking

The registry criteria, word for word

Show all 38 criteriaShow less

Who can take part

Age 50-80 years old
One or more strokes (cerebral infarction or cerebral hemorrhage), with the most recent stroke occurring at least 6 months earlier
Walking independently without a cane or walking aid with obvious gait asymmetry
0.4m/s< baseline velocity <0.8m/s
Sufficient hearing, vision and comprehension to complete motor function tests
Patients were willing and able to participate in all study procedures and signed informed consent
No other rehabilitation treatment was received at present
Age 50-80 years old
PD met the diagnostic criteria of Chinese Diagnostic Criteria for Parkinson's Disease (2016 edition)
Obvious panic gait, freezing gait or slow gait, but can walk independently without the use of a cane or walking aid
Hoehn-Yahr (H-Y) stage 2-4
0.4m/s< baseline velocity <0.8m/s
Sufficient hearing, vision and comprehension to complete motor function tests
Patients were willing and able to participate in all study procedures and signed informed consent
No other rehabilitation treatment was received at present
Age 50-80 years old
All parkinsonism syndrome except primary Parkinson's disease, including but not limited to drug-induced parkinsonism, multiple system atrophy, cerebral small vessel disease-related parkinsonism, etc
obvious panic gait, freezing gait or slow gait, but can walk independently without the use of a cane or walking aid
0.4m/s< baseline velocity <0.8m/s
Sufficient hearing, vision and comprehension to complete motor function tests
Be willing and able to participate in all study procedures and sign informed consent
No other rehabilitation treatment was received at present

Who cannot take part

Uncontrolled hypertension
Myocardial infarction within the past 3 months
With bone and joint diseases, such as a history of lower limb fracture within 1 year, waist and lower limb bone and joint surgery, bone and joint deformity seriously affecting walking, etc
Except for stroke, there was no parkinsonism, myasthenia gravis, poliomyelitis and other nervous system diseases affecting the walking function of patients; For primary Parkinson's disease (PD)
Uncontrolled hypertension
Myocardial infarction within the past 3 months
With bone and joint diseases, such as a history of lower limb fracture within 1 year, waist and lower limb bone and joint surgery, bone and joint deformity seriously affecting walking, etc
There was no stroke, myasthenia gravis, poliomyelitis and other neurological diseases affecting the walking function except for primary Parkinson's disease; For Parkinsonism syndrome:
Uncontrolled hypertension
Myocardial infarction within the past 3 months
With bone and joint diseases, such as a history of lower limb fracture within 1 year, waist and lower limb bone and joint surgery, bone and joint deformity seriously affecting walking, etc
There was no stroke, myasthenia gravis, poliomyelitis and other neurological diseases that affected the walking function except for parkinsonism
Unable to cooperate with the motor function test
Unable to cooperate with the motor function test
Unable to cooperate with the motor function test

Other criteria

For post-stroke hemiplegia

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 50 and 80 years old?

Where in China

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing, ChinaNo longer taking part

About the trial

What the trial wants to find out

The aim of this clinical trial was to determine whether rhythmic auditory stimulation is effective in treating gait disorders in patients with post-stroke hemiplegia, primary Parkinson's disease, and various parkinsonism syndromes. The main questions it aims to answer are:

Read full original descriptionShow less

Does rhythmic auditory stimulation increase walking speed in patients with gait disorders? To determine whether rhythmic auditory stimulation is effective in treating gait disorders, researchers will compare a gait rhythmometer with an active control that does not receive rhythmic stimulation.

Participants will:

Gait training was conducted once a day for 15 minutes for 7 consecutive days Resting-state functional magnetic resonance imaging (fmri) was performed before and after treatment Feedback on subjective improvement at the end of the 7-day treatment

The 2 groups in the trial

Rhythm intervention groupTreatment being tested
Treatment: rhythmic auditory stimulation
Active control groupSham treatment, for comparison
Treatment: No rhythm stimulation