Studies brain signals linked to freezing of gait in Parkinson's disease
Records brain activity with portable EEG in people with Parkinson's and freezing of gait.
Plain-language title generated from the registry record
Registry title: Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease
Key facts
- Where
- Leuven, BelgiumSee the site
Where in Belgium
- Department of rehabilitation sciencesLeuven, BelgiumNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- KU Leuven
- Trial code
- NCT06841718
- Record updated
- 24 February 2025
- Original description
Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments. A major draw-back in the development of better treatments for FOG is the difficulty in detecting episodes and our poor understanding of its underlying pathophysiology.Read full original descriptionShow less
Investigating the Neural Signature of Freezing of Gait Using Ambulatory Electroencephalography in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments. A major draw-back in the development of better treatments for FOG is the difficulty in detecting episodes and our poor understanding of its underlying pathophysiology.
This study will investigate the cortical signature of FOG using ambulatory electroencephalography (EEG) to help improve FOG detection algorithms and provide novel insights into the underlying pathophysiology, which together will guide therapy development.
Inclusion: Clinical diagnosis of Parkinson's disease (PD) made by a Neurologist*; Modified Hoehn \& Yahr (H\&Y) Stage I to IV in the ON medication state; Age above 18 years*; Able to walk 5 minutes while unassisted by a walker or another person (the use of a cane is allowed).*; Mini Mental State Examination>= 21; At least three hours in-between regular medication intakes to allow for stable testing time.*; Self-reported FOG with a severity of at least 1 FOG episode per day, based on items 1 and 2 of the New Freezing of Gait Questionnaire, irrespective of FOG occurring ON- or OFF-medication.*; Stable medication scheme for at least 7 days before enrollment.
Exclusion: Not a stable medication scheme for at least 7 days before the assessment.*; Occurrence of any of the following within 3 months prior to informed consent:; Orthopedic surgery of the lower extremity; Myocardial infarction; Hospitalization for unstable angina; Coronary artery bypass graft; Percutaneous coronary intervention; Implantation of a cardiac resynchronization therapy device; Implantation of deep brain stimulation; Acute musculoskeletal or other neurological, psychiatric, or cardiovascular conditions affecting gait or any other medical condition which, in the opinion of the investigator, may prevent the participant from completing the protocol in full; Participation in another clinical intervention study*; Unable to adhere to assessment procedures leading to missing or unusable data, as determined by the investigators; Substance abuse that may interfere with the patient's compliance.