Magnetic Brain Stimulation Plus Speech Therapy for Mild Stroke Aphasia
Tests magnetic brain stimulation with speech therapy in adults with mild language loss after stroke.
Plain-language title generated from the registry record
Registry title: Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
Key facts
- Where
- Philadelphia, United StatesSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 85 years old?
Source: NCT06842745, who can take part
Where in United States
- University of PennsylvaniaPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pennsylvania
- Trial code
- NCT06842745
- Record updated
- 5 March 2026
- Original description
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.Read full original descriptionShow less
Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.
The main questions this study aims to answer are:
1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment?
Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia.
Participants will:
* Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment
Inclusion: Left Hemisphere stroke; Stroke occurred more than 6 months ago; Mild Aphasia (WAB AQ score > 85); Proficient in English.
Exclusion: Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis); Active psychiatric disorders (i.e. bipolar disorder, schizophrenia); Pacemaker or cardiac defibrillator; Epilepsy, or seizure in the past 6 months; Ongoing substance or alcohol abuse; Diagnosis of tinnitus.