Studying why endurance athletes may develop irregular heartbeat
Compares heart rhythm and heart structure in athletes with and without atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Understanding the Increased Risk of Atrial Fibrillation in Athletes: a Case-control Study
Key facts
- Where
- Leicester, United KingdomSee the site
Where in United Kingdom
- Department of Cardiovascular Sciences. University of Leicester. Glenfield Hospital.Leicester, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Leicester
- Trial code
- NCT06844656
- Record updated
- 25 February 2025
- Original description
Exercise is beneficial to heart health, however, there appears to be a 'U' shaped relationship where too much exercise may increase the risk of an irregular heart rhythm, called atrial fibrillation. Endurance athletes may have up to a 2.5-fold higher risk of developing atrial fibrillation than non-athletic controls.Read full original descriptionShow less
Understanding the Increased Risk of Atrial Fibrillation in Athletes: a Case-control Study
Exercise is beneficial to heart health, however, there appears to be a 'U' shaped relationship where too much exercise may increase the risk of an irregular heart rhythm, called atrial fibrillation. Endurance athletes may have up to a 2.5-fold higher risk of developing atrial fibrillation than non-athletic controls.
The mechanisms behind this increased risk of atrial fibrillation are not the well understood. It is thought to be a mixture of enlarged heart chambers, low resting heart rate, genetic predisposition and possibly scarring in the heart. In this study, the investigators will investigate the electrical activity changes in the heart, using a high-quality electrocardiogram (ECG) and relate this to changes in the heart size measured by ultrasound and MRI. Cardiopulmonary exercise testing will determine fitness (V̇O2 max) and assess the heart's electrical activity during exercise.
This will be a case-control study where athletes with and without atrial fibrillation will be recruited. The investigators hope the results of this study can improve our understanding of atrial fibrillation in athletes by associating atrial fibrillation with structural and electrical differences which may aid the prediction of future atrial fibrillation development and help guide more athlete-specific treatment pathways.
Inclusion: ≥18 years of age at the time of enrolment, male and female; History of atrial fibrillation confirmed on ECG - either paroxysmal or persistent; Competitive athlete. Defined as:; Competed in endurance sports with a total cumulative moderate to high intensity of > 1500 hours; Have participated in at least one competitive event in the last 10 years.
Exclusion: History of pre-existing cardiovascular disease :; Atherosclerotic disease: previous myocardial infarction, symptomatic coronary artery disease or Peripheral peripheral arterial disease; Left ventricular systolic dysfunction (EF < 45%); Heart muscle disease: cardiomyopathies, Infiltrative diseases of the heart; Complex Congenital heart disease; Moderate or severe valvular disease; Uncontrolled hypertension (>180/100mmHg); Permanent atrial fibrillation.