Repeat Ablation Procedure Tested for Persistent Atrial Fibrillation
Tests an added heart procedure against standard repeat ablation in adults with persistent atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Re-ablation of Persistent Atrial Fibrillation
Key facts
- Where
- Århus N, DenmarkSee the site
Where in Denmark
- Department of Cardiology, Aarhus University HospitalÅrhus N, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus University Hospital
- Trial code
- NCT06845085
- Record updated
- 28 February 2025
- Original description
Pulmonary vein re-isolation plus Vein of Marshall ethanol ablation in combination with block of mitral and tricuspid isthmuses and dome line will be compared to pulmonary vein re-isolation alone in patients undergoing re-ablation for persistent atrial fibrillation in this investigator initiated, randomized, patient-assessor blinded multicenter trial. Patients are followed with standard ECG at 3 months, with standard ECG, 5-days' ECG monitoring and quality of life assessment after 12 months, with standard ECG and quality of life assessment after 24 months, through patient files at 60 months after the ablation.Read full original descriptionShow less
Re-ablation of Persistent Atrial Fibrillation: a Randomized Study, Evaluating Vein of Marshall Ethanol Ablation in Combination With Block of Mitral and Tricuspid Isthmuses and Dome Line
Pulmonary vein re-isolation plus Vein of Marshall ethanol ablation in combination with block of mitral and tricuspid isthmuses and dome line will be compared to pulmonary vein re-isolation alone in patients undergoing re-ablation for persistent atrial fibrillation in this investigator initiated, randomized, patient-assessor blinded multicenter trial. Patients are followed with standard ECG at 3 months, with standard ECG, 5-days' ECG monitoring and quality of life assessment after 12 months, with standard ECG and quality of life assessment after 24 months, through patient files at 60 months after the ablation.
Primary endpoint: Change in AFEQT score between baseline and 12 months.
Inclusion: Previous pulmonary vein isolation for atrial fibrillation; Indication for catheter ablation with at least two episodes of symptomatic PsAF during the last 12 months; Age > 18 years; Expected survival > 12 months; Able to provide informed consent.
Exclusion: Previous extrapulmonary atrial ablation other than cavotricuspid isthmus line, roof- or dome line or posterior wall isolation/ablation; Uncontrolled hypertension; Acute coronary syndrome, cardiac surgery, or TIA/stroke within the last 3 months; Planned cardiac surgery within 1 year; Dialysis or severe renal failure; Atypical atrial flutter in addition to atrial fibrillation; Atrial fibrillation secondary to a transient abnormality; Active substance or alcohol abuse (>14 units/week).