Studies whether a cystic fibrosis carrier gene raises the risk of heat stroke
Compares heat and fluid balance in adults who carry a cystic fibrosis gene with controls.
Plain-language title generated from the registry record
Registry title: Genetic Risk Factor for Heat Stroke
Key facts
- Where
- Iowa City, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT06847256, who can take part
Where in United States
- University of Iowa Health CareIowa City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Iowa
- Trial code
- NCT06847256
- Record updated
- 27 April 2026
- Original description
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.Read full original descriptionShow less
Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.
This will be accomplished with two smaller projects- Aim 1 and Aim 2.
Aim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat.
Aim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.
Inclusion: Previously genotyped as a CF carrier or control; Comfortable speaking/reading English.
Exclusion: Previously genotyped as a CF patient; Currently taking beta blockers or diuretics; Diagnosis of Type 1 or Type 2 diabetes; History of heart attack, stroke, heart failure, or atherosclerosis; Currently pregnant; Prisoner status; Unable to provide own written informed consent.