A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)

Prior treatment

• Any major illness or major surgical procedure ≤ 4 weeks before Day 1
• Any febrile illness and associated sequelae ≤ 1 week prior to Day 1
• Active cancer ≤ 1 year prior to Day 1
• Cerebral vascular accident (including stroke and transient ischemic attack) or myocardial infarction ≤ 24 weeks prior to Day 1
• Any panretinal photocoagulation or macular laser photocoagulation treatment prior to Day 1
• Any cataract surgery within 12 weeks prior to Day 1 or any planned surgery during the study
• Intravitreal treatment with an anti-IL-6 (e.g., vamikibart) or anti-IL-6 receptor treatment at any time

Other illness

• History of vitreoretinal surgery/pars plana vitrectomy
• History of any glaucoma surgery including laser glaucoma procedures
• Any active intra- or periocular infection on Day 1
• Any active or history of Intraocular inflammation

Lab values

• HbA1c ≥ 12% at screening

Other

• Uncontrolled glaucoma
• Any proliferative DR

• Diagnosis of diabetes mellitus (type 1 or type 2), as defined by the world health organization (WHO) and/or American Diabetes Association
• Participant consents to AH collection
• Collection of \> 90 microlitres (µL) AH (at each visit required per schedule of activities \[SoA\]) if deemed feasible and safe by the Investigator.
• Macular thickening secondary to DME involving the center of the fovea with CST \>= 325 µm at screening
• Decreased BCVA primarily due to DME with ETDRS score of 78 to 19 letters (both inclusive) at screening
• Adequately clear ocular media and adequate pupillary dilation to allow acquisition of good quality retinal images
• Diagnosis of non-proliferative DR
• Treatment-naive and Pre-treated participants after washout