Magnetic brain stimulation paired with arm training after stroke
Tests magnetic brain stimulation with arm training in adults recovering from stroke.
Plain-language title generated from the registry record
Registry title: Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 80 years old?
Source: NCT06849505, who can take part
Where in China
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical UniversityShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
- Trial code
- NCT06849505
- Record updated
- 27 February 2025
- Original description
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of individualized online rTMS intervention methods. The main questions it aims to answer are:Read full original descriptionShow less
Closed - Loop Neuromodulation of Post - Stroke Motor Dysfunction by Transcranial Magnetic Stimulation Synchronized with Specific Motor Task Training
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of individualized online rTMS intervention methods. The main questions it aims to answer are:
Does rTMS synchronized with motor training improve motor rehabilitation in patients with the ability to induce motor evoked potentials(MEPs)？ Dose individualized rTMS synchronized with motor training improve motor rehabilitation in patients without the ability to induce MEPs? Researchers will compare online rTMS to offline and sham stimulation in patients with MEPs to see if online rTMS works to alleviate motor dysfunction in preliminary trials. And compare individualized online rTMS to non-individualized online rTMS and sham in patients without MEPs to see if individualized online rTMS works to alleviate motor dysfunction in Randomized, double-blinded, and controlled trials.
Participants will:
randomized to one group acoording to the MEP condition of each person; receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.
Inclusion: The patient is first diagnosed with stroke through neurological examination, CT or MRI scan; The vital signs are stable and there is a certain degree of upper limb motor dysfunction; The age is between 20 and 80 years old; The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points; There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition); There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures); The patient or guardian agrees to sign the informed consent form.
Exclusion: Patients with severe heart, lung, liver, kidney diseases and malignant tumors; Those with a history of aphasia, severe cognitive impairment or mental illness; Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently; People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS; Those with severe visual or hearing impairments, unable to communicate normally.