Tests Acoustic Cluster Therapy with chemotherapy for locally advanced pancreatic cancer
Tests sound-wave treatment added to chemotherapy in adults with locally advanced pancreatic cancer.
Plain-language title generated from the registry record
Registry title: Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer
Key facts
- Where
- Cambridge, Hammersmith, and Sutton, United KingdomSee the 3 sites
- Phase
- Phase 2
Where in United Kingdom
- CAMBRIDGE CANCER TRIALS CENTRE-Addenbrooke's HospitalCambridge, United KingdomTaking people
- Gary Weston Centre- Imperial College Healthcare- Du Cane RoadHammersmith, United KingdomTaking people
- The Royal Marsden- Downs RoadSutton, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- EXACT Therapeutics AS
- Trial code
- NCT06850623
- Record updated
- 13 October 2026
- Original description
The purpose of the study is to assess the efficacy and safety of Acoustic Cluster Therapy (ACT) when given in addition to chemotherapy for treatment of Locally Advanced Pancreatic Cancer.Read full original descriptionShow less
A Phase 2 Study to Investigate the Efficacy and Safety of Acoustic Cluster Therapy With Modified FOLFIRINOX in Patients With Locally Advanced Pancreatic Cancer
The purpose of the study is to assess the efficacy and safety of Acoustic Cluster Therapy (ACT) when given in addition to chemotherapy for treatment of Locally Advanced Pancreatic Cancer.
Inclusion: Not deemed suitable for primary curative surgery and have radiographic and pathological disease consistent with inoperable LAPC or borderline resectable pancreatic cancer; Suitable to receive treatment with mFOLFIRINOX according to the Investigator's assessment.
Exclusion: Any prior anti-cancer treatment for pancreatic cancer (e.g. chemotherapy, surgery, radiation). Palliative bypass procedure and bile duct stenting are allowed.