Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
Key facts
- Where
- São Paulo, BrazilSee the site
Where in Brazil
- Federal University of Sao Paulo - Hospital Sao Paulo,São Paulo, BrazilContact: Leonardo Ferraro, MD, PHDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Federal University of São Paulo
- Trial code
- NCT06858228
- Record updated
- 11 March 2025
- Original description
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief.Read full original descriptionShow less
Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: a Randomized Clinical Trial of Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief.
Inclusion: Adults aged ≥ 18 years; Knee pain for more than 3 months; Clinical and imaging-confirmed diagnosis of knee osteoarthritis, based on X-ray, ultrasound, or magnetic resonance imaging (MRI).
Exclusion: History of major joint interventions, such as previous knee surgery or arthroplasty; Coagulation disorders or other clinical contraindications for the procedure; Cognitive impairment that affects the ability to understand and respond to pain assessment instruments; Severe joint effusion; Uncontrolled comorbidities that increase procedural risk; Body mass index (BMI) > 35.