Studying how endoscopic treatment works for varices in cirrhosis patients
Observes endoscopic treatment of esophageal and gastric varices in adults with cirrhosis.
Plain-language title generated from the registry record
Registry title: Evaluation of Endoscopic Treatment Effect Based on HVPG
Key facts
- Where
- Hangzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with cirrhosis who have varices in the esophagus and stomach and have bled from them before. It studies how endoscopic treatment works, measured by portal pressure (HVPG).
- Age
- 18-80 years
- Sex
- All sexes can join.
- Disease stage
- Cirrhosis confirmed by clinical, imaging or pathology findings. Varices in the esophagus and stomach confirmed by endoscopy, with varicose vein bleeding in the past.
- Earlier treatment
- Endoscopic treatment (such as band ligation, sclerotherapy or colloid injection) must be an appropriate way to prevent more bleeding. Cannot have had TIPS, liver transplantation or other treatments that may affect the study within the past 6 months.
Main reasons for not taking part
- Hepatocellular carcinoma or other cancers
- Autoimmune cirrhosis, schistosomal cirrhosis or hepatic venous occlusion
- Other diseases that affect portal hypertension, such as portal vein thrombosis
- TIPS, liver transplantation or similar treatment within 6 months
- Severe heart or lung disease, such as severe heart failure or COPD
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06863519, who can take part
Where in China
- Second Affiliated Hospital, School of Medicine, Zhejiang UniversityHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Trial code
- NCT06863519
- Record updated
- 7 March 2025
- Original description
This study aims to evaluate the endoscopic treatment effect and related influencing factors of patients with esophageal and gastric varices based on HVPG. By enrolling and collecting patients with esophageal and gastric varices at different stages of liver cirrhosis, the changes in portal pressure before and during endoscopic treatment were detected. The endoscopic treatment effect of different patients was evaluated by combining the changes in HVPG and the condition of varicose veins, the effects of different endoscopic treatment methods on HVPG were analyzed, and the correlation between HVPG changes and endoscopic efficacy was explored.Read full original descriptionShow less
Evaluation of Endoscopic Treatment Effect and Influencing Factors in Patients With Esophageal and Gastric Varices in Cirrhosis Based on HVPG
This study aims to evaluate the endoscopic treatment effect and related influencing factors of patients with esophageal and gastric varices based on HVPG. By enrolling and collecting patients with esophageal and gastric varices at different stages of liver cirrhosis, the changes in portal pressure before and during endoscopic treatment were detected. The endoscopic treatment effect of different patients was evaluated by combining the changes in HVPG and the condition of varicose veins, the effects of different endoscopic treatment methods on HVPG were analyzed, and the correlation between HVPG changes and endoscopic efficacy was explored.
Inclusion: Age range: 18-80 years old; Patients with confirmed cirrhosis through clinical, imaging or pathological evidence, with causes including viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, etc; Patients with esophageal and gastric varices confirmed by endoscopic examination and varicose vein bleeding in the past; Endoscopic treatment (such as band ligation, sclerotherapy or colloid injection) is an appropriate secondary prevention method.
Exclusion: (1) Combined with hepatocellular carcinoma or other malignant tumors; (2) Autoimmune cirrhosis, schistosomal cirrhosis, hepatic venous occlusion, etc.; (3) Combined with other diseases that affect portal hypertension, such as portal vein thrombosis; (4) Recently (within 6 months) received other treatments, such as TIPS, liver transplantation, or other treatment measures that may affect the study; (5) Accompanied by severe cardiopulmonary diseases (such as severe heart failure, COPD, etc.).