Tests metoprolol against placebo for blood flow in the heart's small vessels
Tests metoprolol against a placebo in adults with angina and no blocked coronary arteries.
Plain-language title generated from the registry record
Registry title: Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Key facts
- Where
- Aalst, BelgiumSee the site
- Phase
- Phase 4
Where in Belgium
- OLV Cardiovascular Center AalstAalst, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VZW Cardiovascular Research Center Aalst
- Trial code
- NCT06864234
- Record updated
- 14 July 2025
- Original description
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).Read full original descriptionShow less
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
The main questions it aims to answer are:
* Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients?
Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation.
Participants will:
* Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.
Inclusion: Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR >0.80 and no diameter stenosis >50%; Normal, TIMI 3 flow at angiography; Stable haemodynamics.
Exclusion: Clinical signs or symptoms of congestive heart failure; Severe valvular heart disease requiring either surgical or percutaneous intervention; History of coronary artery bypass grafting; Heart rate <60 beats per minute; LVEF<40%; Tortuous coronary anatomy in which wire manipulation could be complex; Systolic blood pressure <100 mmHg; Unable to give consent.