Studies blood pressure swings and frailty in older adults
Observes whether low daytime blood pressure links to later falls or hospital stays.
Plain-language title generated from the registry record
Registry title: Study on Blood Pressure Variability and Frailty in the Older People
Key facts
- Where
- Milan, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 75 or older who have been diagnosed with high blood pressure. It studies how blood pressure changes during the day and how this relates to frailty and health problems later.
- Age
- 75 years or older
- Sex
- All sexes can join.
- Disease stage
- Diagnosis of hypertension (high blood pressure) according to the European Society of Cardiology guidelines.
Main reasons for not taking part
- The person or their legal representative refuses to take part
- Life expectancy of less than 6 months
Read by machine on 12 November 2026.
Where in Italy
- Istituto Auxologico Italiano IRCCSMilan, ItalyContact: Alessandro Croce, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Istituto Auxologico Italiano
- Trial code
- NCT06868069
- Record updated
- 30 March 2026
- Original description
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) <90 mmHg (or two episodes of daytime SBP <90 mmHg, if mean 24 h SBP is <125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)Read full original descriptionShow less
Study on Blood Pressure Variability and Frailty in the Older People: the HypoPHrail Study
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) <90 mmHg (or two episodes of daytime SBP <90 mmHg, if mean 24 h SBP is <125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)
Inclusion: Age ≥ 75 years; Diagnosis of hypertension according to the criteria of the European Society of Cardiology guidelines [Williams 2018]; Consent of the patient (or legal representative) to participate in the study.
Exclusion: Refusal of the patient or his/her legal representative; Life expectancy of less than 6 months.