Studies red blood cell flexibility in people with end-stage kidney disease
Observes how red blood cell flexibility relates to exercise capacity in adults with kidney failure.
Plain-language title generated from the registry record
Registry title: Rheological Functions of Erythrocyte in ESRD
Key facts
- Where
- Taoyuan, TaiwanSee the site
Where in Taiwan
- Chang Gung UniversityTaoyuan, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chang Gung Memorial Hospital
- Trial code
- NCT06868888
- Record updated
- 11 March 2025
- Original description
End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunctionRead full original descriptionShow less
The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients
End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction
Inclusion: Receiving hemodialysis and medication at least for 6 weeks; Kt/V score > 1.2.
Exclusion: Having orthopedic or muscular diseases; Other concerned medical, psychological or physiological diseases; Under 20 years-old; Hyperkalemia occurs within 3 month; Pregnancy; Other exercise contraindications.