Tests mindfulness group therapy for people at high risk of psychosis
Tests a group mindfulness programme in young adults at high risk of psychosis.
Plain-language title generated from the registry record
Registry title: Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
Key facts
- Where
- Brest and Laxou, FranceSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 30 years old?
Source: NCT06870305, who can take part
Where in France
- Centre Hospitalier Universitaire (CHU) de BrestBrest, FranceNo longer taking part
- Centre Psychothérapique de NancyLaxou, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Psychothérapique de Nancy
- Trial code
- NCT06870305
- Record updated
- 25 March 2026
- Original description
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment. The secondary objectives were to study the efficacy of a group-based mindfulness intervention: on the reduction of psychotic symptoms; on the maintenance over time (6 months of follow-up) of the efficacy of the intervention on the distress associated with the symptoms of the UHR or PEP state; and on various dimensions associated with care: cognitive functions, anxiety, quality of life.Read full original descriptionShow less
Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment. The secondary objectives were to study the efficacy of a group-based mindfulness intervention: on the reduction of psychotic symptoms; on the maintenance over time (6 months of follow-up) of the efficacy of the intervention on the distress associated with the symptoms of the UHR or PEP state; and on various dimensions associated with care: cognitive functions, anxiety, quality of life.
Inclusion: People aged between 18 and 30 validating the criteria for UHR or PEP status on the CAARMS scale and having a social functional impact (SOFAS score below 50 or a reduction of more than 30% in the score).
Exclusion: Previous episode of schizophrenic disorder, schizoaffective disorder or bipolar disorder; Previous antipsychotic treatment for more than 12 months; Organic mental disorder or intellectual disability; Serious suicidal/homicidal risk (but admissible if this risk has been resolved); Insufficient French language skills; Adult incapable of giving consent and not under legal protection; Protection measure (guardianship/curatorship/court supervision) or under court supervision; Person deprived of liberty by judicial or administrative decision (including forced hospitalisation); Persons in a life-threatening emergency; Not affiliated to a social security regime.