Muscle Loss and Breathlessness in People With Asthma
This study looks at how muscle loss affects shortness of breath in adults with asthma.
Plain-language title generated from the registry record
Registry title: Impact of Sarcopenia on Dyspnea in Patients With Asthma
Key facts
- Where
- Clermont-Ferrand, FranceSee the site
Where in France
- CHU Clermont-FerrandClermont-Ferrand, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Clermont-Ferrand
- Trial code
- NCT06870890
- Record updated
- 11 March 2025
- Original description
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses.Read full original descriptionShow less
Impact of Sarcopenia on Dyspnea in Patients With Asthma
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses.
The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea .
The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction.
The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.
Inclusion: Age ≥ 18 years; Patient affiliated to a social security scheme; Patient capable of giving free, informed, written and signed consent; Asthmatic patients with a diagnosis made by a pulmonologist on GINA level 4 or 5 treatment; ACT asthma control score < 20; Patient judged by the investigator to be able to to perform a maximal exercise test.
Exclusion: Unstable heart disease; Patient under guardianship/trusteeship/supervision of justice; Pregnant or breast-feeding women; Patients who have been smoking or have stopped smoking for less than 5 years,.