Exploring Water-free Sodium Storage
Key facts
- Where
- New Haven, United StatesSee the site
Where in United States
- Yale UniversityNew Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT06872645
- Record updated
- 13 May 2026
- Original description
The overarching goal of this proposal is to definitively establish if acute water free Na storage and release occurs, if the amount stored/released is of a quantity that is physiologically relevant, and if the location is intracellular vs. extracellular.Read full original descriptionShow less
The overarching goal of this proposal is to definitively establish if acute water free Na storage and release occurs, if the amount stored/released is of a quantity that is physiologically relevant, and if the location is intracellular vs. extracellular.
Inclusion: ESRD Patients actively undergoing PD with a reliably functioning PD catheter; Systolic blood pressure > 130 mmHg; Serum sodium >135 mmol/L; daily urine output < 400ml; stable PD prescription for at least 2 months without requirement of 4.25% glucose PD solution; PD vintage of at least 6 months; Euvolemic as defined by the patient at their dry weight and free of any signs or symptoms of volume overload, per referring nephrologist.
Exclusion: 1 or more episodes of peritonitis in the previous 6 months or active infection of the peritoneal dialysis catheter; Poorly controlled diabetes with hemoglobin A1C>9%; Anemia with hemoglobin <8g/dL; gastrointestinal disease that causes diarrhea or expectation of sodium losses in stool; Inability to give written informed consent or follow study protocol; Urinary incontinence; Body weight < 60kg; use of amiodarone in the last 6 months (which will interfere with tissue iodine ascertainment).