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MRI Scans to Guide Fertility-Sparing Care for Early Cervical Cancer

Studies MRI scans in women with early cervical cancer who want to keep fertility.

Key facts

Who runs it
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Where
Rome, ItalySee the site
Trial code
Registry title
Role of MRI Assessment in Fertility Sparing Treatment for Cervical Cancer at Staging and Follow-up and for Identification of Risk Factors for Aggressive Disease.
Status
Recruiting
People taking part
60 people, planned
Started
1 Mar 2024
Expected to end
31 Dec 2028
Type of study
Observational, 2 groups
Record updated
14 March 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women with early cervical cancer (tumour under 4 cm (1.6 in), no lymph node disease) who want to keep their fertility and refuse radical treatment. They need MRI scans before and after treatment.

Age
18 years or older
Sex
Women only
Disease stage
Cervical cancer FIGO stage up to IB2-IIA1, tumour size under 4 cm (1.6 in), no lymph node disease
Earlier treatment
Treated at the Oncological Gynecology Unit of Foundation Policlinico Universitario Agostino Gemelli; must have had an MRI scan before and after treatment

Main reasons for not taking part

  • Under 18 years old
  • Neuroendocrine tumour or other rare cell types, such as glassy cell or clear cell carcinoma, or non-HPV related adenocarcinoma
  • Pregnant at the time of diagnosis
  • No digital MRI images available, or images of low quality
  • Already in menopause

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Patients with cervical cancer FIGO stage up to IB2-IIA1 (T size < 4 cm) wishing to preserve fertility treated at the Oncological Gynecology Unit of Foundation Policlinico Universitario Agostino Gemelli
  • absence of nodal disease,
  • no menopausal status
  • wish to preserve fertility
  • refusal of radical treatment
  • Patients who had a pre-treatment and post-treatment magnetic resonance imaging
  • Availability of digital MR images and histopathological samples

Who cannot take part

  • Patients aged under 18 years
  • Neuroendocrine cervical tumours or other rare histology, such as glassy cells or clear cell carcinoma non-HPV related adenocarcinoma
  • ongoing pregnancy at the time of diagnosis
  • Patients without available MR images on digital media or with low quality images

Where in Italy

  • Advanced Radiology Center- Fondazione Policlinico Universitario A. Gemelli IRCCSRome, ItalyContact: Benedetta GuiTaking people

About the trial

What the trial wants to find out

The purpose of this study is to investigate the role of MRI, including DWI, in the staging and evaluation of response to fertility sparing treatment, including both primary surgery Protocol FeST-CC V.1.0 of November 10, 2023 Pag. 5 | 23 (RT or CKC) or after NACT, followed by CKC, in patients with ECC (FIGO 2018 stage IB1- IIA1), desiring to preserve their fertility.

The 2 groups in the trial

  • Retrospective cohort

    In the retrospective phase of the research, all patients with histological diagnosis of cervical cancer, stage FIGO up to IB2-IIA1 (T size \< 4 cm), treated with fertility sparing techniques, from 2018 to 2023, will be identified retrospectively, searching on RedCap database. Of these patients, only those with good quality of MR images (available on digital support) will be selected.

  • Prospective cohort

    In the prospective phase of the research, all patients with histological diagnosis of cervical cancer, FIGO stage up to IB2-IIA1 (T size \< 4 cm), that wish to preserve fertility and are suitable for fertility sparing treatments. Of these patients, only those with good quality of MR images (available on digital support) will be selected.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Role of MRI Assessment in Fertility Sparing Treatment for Cervical Cancer at Staging and Follow-up and for Identification of Risk Factors for Aggressive Disease.
Plain-language title
MRI Scans to Guide Fertility-Sparing Care for Early Cervical CancerGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
14 March 2025