Two smartphone apps tested to help people with HIV quit smoking
Compares two smartphone apps helping adults living with HIV quit smoking.
Plain-language title generated from the registry record
Registry title: Quitting Matters Human Immunodeficiency Virus Hybrid Trial
Key facts
- Where
- Winston-Salem, United StatesSee the site
Where in United States
- Wake Forest University, Implementation ScienceWinston-Salem, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University Health Sciences
- Trial code
- NCT06883097
- Record updated
- 30 September 2026
- Original description
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH). Participants will complete a 24- week (~6-month) study where the Participants will be assigned to one of two smartphone apps to help with quitting smoking. Regardless of the group participants are assigned to, they will also receive a combination of nicotine replacement therapy (patches and gums) that have been shown to help people quit smoking. The main questions this study aims to answer are:Read full original descriptionShow less
Hybrid Trial of a Digital Therapeutic for Smoking Cessation Among Persons Living With HIV
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH). Participants will complete a 24- week (~6-month) study where the Participants will be assigned to one of two smartphone apps to help with quitting smoking. Regardless of the group participants are assigned to, they will also receive a combination of nicotine replacement therapy (patches and gums) that have been shown to help people quit smoking. The main questions this study aims to answer are:
Participants will complete 6 video call visits over about 6 months. Participants will install their assigned smoking cessation app onto their phone and will be asked to use the app for the duration of the study along with their provided Nicotine Replacement Therapy (NRT) products. During the study visits, participants will meet with study staff to complete questionnaires and interviews. Participants may be asked to provide breath and saliva samples to measure the level of carbon monoxide and nicotine.
Inclusion: Self-reported daily cigarette smoking over the past 30 days; Self-reported HIV status; Age 18 or older; Desire to quit smoking; Willing and medically eligible to use NRT; Currently receiving HIV care; Currently owning an Android or iOS smartphone.
Exclusion: Currently receiving any pharmacological and/or behavioral intervention or counseling for smoking cessation; Any medical condition or medication that could compromise subject safety, as determined by the PIs and/or study physician; Current acute psychotic episode or unsafe to participate in the study; Pregnant or intending to become pregnant in the next 6 months; Not able to fluently speak and write in English; Hearing, comprehension, visual, speech, or motor limitations that preclude study participation.