Tests low-valine meal replacements in people with overweight or obesity
Compares low-valine and ordinary meal replacements for weight and related metabolic health in adults.
Plain-language title generated from the registry record
Registry title: Effect of Low Valine Diet on Body Weight and Metabolic Parameters
Key facts
- Where
- Shanghai, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for overweight or obese adults and teens aged 16 to 80. It compares ordinary meal replacements with low-valine meal replacements.
- Age
- 16 to 80 years old
- Sex
- Men and women can join.
- Disease stage
- Overweight or obesity, with a BMI of 24kg/m2 or higher.
- Earlier treatment
- People who took drugs that may change weight for more than 2 weeks in the past year cannot join. Examples are glucocorticoids and thyroid hormones. People who had stomach volume reduction surgery or digestive tract surgery cannot join.
Main reasons for not taking part
- Heavy drinking in the past 6 months (men over 140g and women over 70g of alcohol per week)
- Liver disease from other causes, such as viral hepatitis or cirrhosis
- Poorly controlled diabetes (HbA1c above 9.5% (80 mmol/mol) within three months)
- Chronic kidney disease or serum creatinine above 2.0mg/dL (177 µmol/L)
- Any tumor disease
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 80 years old?
Source: NCT06883578, who can take part
Where in China
- Zhongshan Hospital,Fudan UniversityShanghai, ChinaContact: Mingfeng XiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Shanghai Zhongshan Hospital
- Trial code
- NCT06883578
- Record updated
- 19 March 2025
- Original description
This study aimed to explore the effects of ordinary meal replacements and low-valine meal replacements on the weight and risk of related metabolic diseases in overweight/obese patients through a randomized double-blind controlled clinical trial.Read full original descriptionShow less
Effect of Low Valine Diet on Body Weight and Metabolic Parameters
This study aimed to explore the effects of ordinary meal replacements and low-valine meal replacements on the weight and risk of related metabolic diseases in overweight/obese patients through a randomized double-blind controlled clinical trial.
Inclusion: Male or female, 16 years old ≤ age ≤ 80 years old; BMI ≥ 24kg/m2.
Exclusion: Continuously used drugs that may cause weight changes for more than 2 weeks in the past year (such as glucocorticoids, thyroid hormones, etc.); Those who had gastric volume reduction surgery or digestive tract surgery; Liver diseases caused by other reasons: such as alcoholic liver disease, acute and chronic viral hepatitis, drug-induced, immune hepatitis (AMA, SMA, ANA), cirrhosis, liver cancer, etc; Life expectancy of no more than 3 years in the presence of serious health conditions; Those who cannot participate in the follow-up of the intervention due to other conditions; Those diagnosed with any tumor disease; Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, Cushing's syndrome, etc; Poorly controlled diabetic patients: HbA1c >9.5% within three months; or use of hypoglycemic drugs that may affect weight, including pioglitazone, GLP-1, SGLT2 inhibitors; Chronic kidney disease or severe renal impairment, defined as serum creatinine greater than 2.0mg/dL; Serum ALT greater than 3 times the upper limit of normal; Excessive drinkers (defined as: in the past 6 months, the weekly alcohol intake of men exceeds 140g, and that of women exceeds 70g); Those who plan to get pregnant in the near future; Participated in other clinical trials in the past 4 weeks; Subjects who participated in strenuous exercise or planned to change their diet structure; Unable to sign the informed consent form.