Tests an anti-inflammatory diet before IVF in women with endometriosis
Tests an anti-inflammatory diet in women with endometriosis having IVF.
Plain-language title generated from the registry record
Registry title: Dietary Intervention to Improve Fertility in Women With Endometriosis Undergoing IVF
Key facts
- Where
- Milan, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 39 years old?
Source: NCT06885125, who can take part
Where in Italy
- Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Trial code
- NCT06885125
- Record updated
- 2 November 2026
- Original description
The goal of this randomized controlled trial is to assess whether a 12-week anti-inflammatory diet can improve fertility outcomes in women with endometriosis undergoing In Vitro Fertilization (IVF).Read full original descriptionShow less
Randomized Controlled Study on the Effect of a DietAry interveNtion in Ameliorating fertiliTy Parameters in Women With endomEtriosis Undergoing IVF (The DANTE Study)
The goal of this randomized controlled trial is to assess whether a 12-week anti-inflammatory diet can improve fertility outcomes in women with endometriosis undergoing In Vitro Fertilization (IVF).
The main questions are:
* Does the anti-inflammatory diet reduce the rate of inadequate ovarian response to hormonal stimulation (retrieval of ≤3 oocytes)? * Does it improve secondary outcomes such as embryo quality, pregnancy rates, inflammation markers, and quality of life?
Researchers will compare two groups:
* Women receiving standard IVF protocols. * Women undergoing the same IVF protocol plus the anti-inflammatory diet.
Participants will:
* Be randomized into one of the two groups. * Follow dietary counseling sessions and complete dietary assessments (diet group). * Provide biological samples (e.g., plasma, vaginal and fecal swabs, and follicular fluid) before and after the dietary intervention to evaluate potential differences in inflammation, hormonal levels, and microbiome composition between the two groups and across timepoints (pre- and post-diet). * Complete questionnaires on quality of life, sexual function, and symptomatology severity before and after the intervention to assess differences between the two groups and across timepoints.
Inclusion: Age < 40 years; Pregnancy seeking for more than 12 months; Regular menstrual cycle, i.e. mean cycle interval between 21 and 35 days; Ultrasonographic diagnosis of ovarian endometriomas or deep peritoneal endometriosis; Antral Follicle Counts (AFC) ≥ 5 (no other cause of reduced ovarian reserve); Absence of ureteral stenosis or intestinal subocclusive symptoms.
Exclusion: Doubtful sonographic findings that do not allow to reliably rule out malignancy; Contraindication to pregnancy; Hydrosalpinx; Endometriomas with a mean diameter > 4 cm; Submucosal fibroids or large intramural or subserosal fibroids (≥ 5 cm); severe male factor (<1 million sperm/ml).