Fasting and exercise effects in people with metabolic syndrome
Tests fasting, with or without interval training, in adults with obesity and metabolic syndrome.
Plain-language title generated from the registry record
Registry title: Effects of Intermittent Fasting and Exercise on Inflammation, Metabolism, and the Microbiome in Metabolic Syndrome
Key facts
- Where
- Erlangen, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06885255, who can take part
Where in Germany
- Hector-Center for Nutrition, Exercise and Sports, University Hospital ErlangenErlangen, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Erlangen-Nürnberg Medical School
- Trial code
- NCT06885255
- Record updated
- 20 March 2025
- Original description
The goal of this intervention trial is to assess the effects of intermittent fasting, both alone and in combination with high-intensity interval training, on patients with obesity and metabolic syndrome. The main question it aims to answer is:Read full original descriptionShow less
Effects of Intermittent Fasting and Its Combination with High-Intensity Interval Training on Inflammatory and Metabolic Markers, As Well As the Microbiome in Patients with Metabolic Syndrome: a Randomized Controlled Pilot Study
The goal of this intervention trial is to assess the effects of intermittent fasting, both alone and in combination with high-intensity interval training, on patients with obesity and metabolic syndrome. The main question it aims to answer is:
Does intermittent fasting, with or without high-intensity interval training, reduce chronic inflammation in patients with obesity and metabolic syndrome?
Participants will follow an intermittent fasting regime for 3 months, with one intervention group additionally participating in high-intensity interval training twice a week. In addition, there are two control groups: one consisting of participants with metabolic syndrome and one consisting of generally healthy individuals. The study includes a 3-month intervention phase followed by a 3-month follow-up phase. During the 6-month study period, all participants will attend 6 in-house study visits and 2 phone visits, during which they will undergo assessments and receive nutritional counseling.
Inclusion: Written consent to participate in the study; Persons aged 18 years and older; Diagnosis of Metabolic Syndrome (MetS) with elevated hsCRP.
Exclusion: Use of medication or supplements that significantly affect study outcomes (e.g., anti-inflammatory medications, antibiotics within the last 6 weeks); Cardiovascular diseases or orthopedic restrictions that prevent exercise; Individuals with mental illnesses that may impair their ability to understand or participate in the study; Pregnant or nursing individuals; Body weight greater than 200 kg (maximum capacity of training equipment).