Smartphone virtual and augmented reality training for arm recovery after stroke
Tests a smartphone virtual reality app for arm and thinking training at home after stroke.
Plain-language title generated from the registry record
Registry title: Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE)
Key facts
- Where
- Cluj-Napoca, RomaniaSee the site
Where in Romania
- RoNeuro Institute for Neurological Research and DiagnosticsCluj-Napoca, RomaniaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eodyne Systems SL
- Trial code
- NCT06885502
- Record updated
- 6 January 2026
- Original description
This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke. The study focuses on combined motor and cognitive training for patients in the late subacute and chronic phases post-stroke. The intervention is provided through the Rehabilitation Gaming System application RGSapp, a goal-oriented, first-person virtual reality (VR) and augmented reality (AR) mobile application for upper limb rehabilitation. A total of seventy participants will be randomly assigned (1:1 ratio) to either the RGSapp intervention or conventional therapy/standard of care for six weeks. The primary outcome is motor function improvement (upper limb), assessed using the Action Research Arm Test (ARAT). Secondary outcomes include changes in cognitive function, depression, usability, adherence, validity of remote assessments, and healthcare costs.Read full original descriptionShow less
Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE): A Randomized Clinical Trial
This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke. The study focuses on combined motor and cognitive training for patients in the late subacute and chronic phases post-stroke. The intervention is provided through the Rehabilitation Gaming System application RGSapp, a goal-oriented, first-person virtual reality (VR) and augmented reality (AR) mobile application for upper limb rehabilitation. A total of seventy participants will be randomly assigned (1:1 ratio) to either the RGSapp intervention or conventional therapy/standard of care for six weeks. The primary outcome is motor function improvement (upper limb), assessed using the Action Research Arm Test (ARAT). Secondary outcomes include changes in cognitive function, depression, usability, adherence, validity of remote assessments, and healthcare costs.
Inclusion: Patients presenting an ischemic or intracerebral haemorrhagic stroke, ≥ 3 months post-stroke; Age > 18 years old; Moderate to mild proximal upper limb motor impairment Medical Research Council Scale (MRC >2); ARAT: <50, inclusive, to avoid ceiling effects while allowing room for improvement; Able to sit on a chair or a wheelchair to interact with the RGS system; Minimal experience with smartphone technology based on the clinician's opinion; Willing to participate and agree to comply with the trial scheme and procedures; Must sign an Informed Consent Form (ICF) indicating that they understand the purpose and the procedures of the study.
Exclusion: Presence of a condition or abnormality that, in the opinion of the investigator, would compromise the safety of the patient or the quality of the data; Pre-stroke history of upper limb motor disability; Severe cognitive capabilities that prevent the execution of the study, evaluated by the MoCA < 19 or based on the clinician's opinion; Unable to use the RGS independently, according to the clinician's observations, and needing more support from a caregiver to use the RGS.