Audio-visual perception tests for early detection of schizophrenia
Tests sound and sight perception in adults with schizophrenia and healthy people.
Plain-language title generated from the registry record
Registry title: An Integrated Neurophysiological Approach Toward the Early Detection of Psychiatric Disorders
Key facts
- Where
- Brescia, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06886945, who can take part
Where in Italy
- IRCCS Centro San Giovanni di Dio FatebenefratelliBrescia, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
- Trial code
- NCT06886945
- Record updated
- 20 March 2025
- Original description
Schizophrenia (SCZ) is a severe neuropsychiatric disorder characterized by cognitive decline, social withdrawal, and positive symptoms such as hallucinations and delusions. Research suggests that SCZ and schizotypy exist along a continuum, with shared structural and behavioral abnormalities, the latter of which encompass the sensory and perceptual domain, often in the form of altered multisensory integration, as seen in tasks like the Sound-Induced Flash Illusion (SIFI). Individuals with schizotypal traits or SCZ show enlarged temporal binding windows (TBW) of cross-modal integration, affecting perceptual accuracy and multisensory judgments. However, whether these deficits stem from overactive top-down modulation or weakened bottom-up sensory precision remains unclear.Read full original descriptionShow less
An Integrated Neurophysiological Approach Toward the Early Detection of Psychiatric Disorders
Schizophrenia (SCZ) is a severe neuropsychiatric disorder characterized by cognitive decline, social withdrawal, and positive symptoms such as hallucinations and delusions. Research suggests that SCZ and schizotypy exist along a continuum, with shared structural and behavioral abnormalities, the latter of which encompass the sensory and perceptual domain, often in the form of altered multisensory integration, as seen in tasks like the Sound-Induced Flash Illusion (SIFI). Individuals with schizotypal traits or SCZ show enlarged temporal binding windows (TBW) of cross-modal integration, affecting perceptual accuracy and multisensory judgments. However, whether these deficits stem from overactive top-down modulation or weakened bottom-up sensory precision remains unclear.
The current study seeks to address these questions, by asking participants (healthy individuals screened as for their schizotypal traits, and patients suffering from SCZ) to complete a modified version of the SIFI, as well as an audiovisual temporal order judgment (TOJ) task. Cross-modal performance will be assessed via signal detection theory (SDT) metrics and psychometric modeling to estimate individual TBWs, thereby assaying audiovisual processing abilities along the schizotypal continuum
Inclusion: Normal hearing; Normal or corrected-to-normal vision; Clinical diagnosis of schizophrenia spectrum disorder (according to DSM-5); IQ > 70.
Exclusion: Drug dependency/abuse over the last 6 months; Unstable pharmacological therapy; Current major physical illness; Comorbidities with other major psychiatric disorders; Anamnesis or evidence of any central nervous system alteration.