Liver-directed chemotherapy pump after surgery for bile duct cancer in the liver
Tests a chemo pump in adults with liver bile duct cancer after surgery.
Plain-language title generated from the registry record
Registry title: Additional Chemotherapy Administered Directly Into the Liver Using a Chemo Pump in Patients With Bile Duct Cancer Inside the Liver Treatable by Surgery
Key facts
- Where
- Amsterdam, Groningen, Maastricht, Rotterdam, and Utrecht, NetherlandsSee the 5 sites
- Phase
- Phase 2
Where in Netherlands
- Amsterdam UMCAmsterdam, NetherlandsTaking people
- Universitair Medisch Centrum GroningenGroningen, NetherlandsTaking people
- Maastricht University Medical Center+ (MUMC+)Maastricht, NetherlandsTaking people
- Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)Rotterdam, NetherlandsTaking people
- Universitair Medisch Centrum UtrechtUtrecht, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Erasmus Medical Center
- Trial code
- NCT06888063EU 2024-513726-33-00
- Record updated
- 23 September 2026
- Original description
The goal of this clinical trial is to learn if additional chemotherapy by means of a chemo pump can prevent return of disease in adult patients with bile duct cancer in the liver that can be treated with surgery. The main questions it aims to answer are:Read full original descriptionShow less
Preventing Liver Recurrence After Partial Hepatectomy for Intrahepatic Cholangiocarcinoma Using Adjuvant Hepatic Arterial Infusion Pump Chemotherapy - PUMP IV Trial
The goal of this clinical trial is to learn if additional chemotherapy by means of a chemo pump can prevent return of disease in adult patients with bile duct cancer in the liver that can be treated with surgery. The main questions it aims to answer are:
* Does addition of chemotherapy by means of a chemo pump lead to less return of disease within the liver two years after surgery? * Does addition of chemotherapy by means of a chemo pump lead to longer survival of patients? * Does addition of chemotherapy by means of a chemo pump lead to an increase in quality of life?
Participants will receive an implanted chemo pump, through which additional chemotherapy will be given to the liver in addition to surgery.
Inclusion: 18 years or older; ECOG or WHO performance status 0 or 1; Diagnosis of resectable iCCA on imaging. No histological confirmation is needed before surgery, according to standard of care; Patient is able to undergo a laparotomy; Positioning of a catheter for HAIP chemotherapy is technically feasible based on a CT-scan with early arterial phase with 1mm cuts. The default site for the catheter insertion is the GDA. Accessory or aberrant hepatic arteries are no contraindication for catheter placement; Adequate bone marrow, liver, and renal function before inclusion (values may be max. 30 days old); Absolute neutrophil count (ANC) ≥ 1.5 x 10\^ 9/L; White blood cell count (WBC) ≥ 2.5 x 10\^9/L; Platelets ≥ 100 x 10\^9/L; Glomerular filtration rate (GFR) ≥ 30 ml/min; Haemoglobin (Hb) ≥ 5.5 mmol/L; Total bilirubin ≤ 25 µmol/L; Written informed consent must be given according to ICH/good clinical practice (GCP), and national/local regulations.
Exclusion: Second primary malignancy, except for adequately treated non-melanoma skin cancer, or other malignancy treated at least 3 years previously without evidence of recurrence or with a life expectancy longer than 5 years; Prior hepatic radiation, ablation, or resection for iCCA; Serious concomitant systemic disorders that would compromise the safety of the patient or his/her ability to complete the study, at the discretion of the investigator; Organ allografts requiring immunosuppressive therapy; Presence of extrahepatic disease at the time of first presentation. Patients with locoregional lymph node disease or with small (≤ 1 cm) extrahepatic lesions that are too small to characterize or biopsy are eligible; Clinical evidence of portal hypertension (ascites, gastroesophageal varices, or portal vein thrombosis). Some postoperative ascites is allowed; (Partial) portal vein thrombosis in future liver remnant; History of psychiatric disability judged by the investigator to be clinically significant, precluding informed consent or interfering with compliance for HAIP chemotherapy; Serious infections (uncontrolled or requiring treatment); Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial; Known homozygous dihydropyrimidine dehydrogenase (DPYD) deficiency; Pregnant or lactating women; Participation in another interventional study for iCCA with survival as outcome; Participation in another prospective study with an interventional medical product.