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Taking people in United StatesNo phase

Study of an Oral Fluid Testing Approach

Key facts

Who runs it
Boston Children's Hospital
Where
Boston, United StatesSee the site
Trial code
Status
Recruiting
People taking part
200 people, planned
Started
27 Oct 2025
Expected to end
Jun 2027
Type of study
Observational
Treatments tested
  • Biologic testing for THC
Record updated
6 November 2026

Who can take part

Age
18 years to 35 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

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Who can take part

  • Age 18 to 35 years
  • Cannabis use on >=1x/week in the past 30 days
  • Ownership of a portable device that is capable of videoconference and videorecording (i.e., smartphone, tablet computer, or laptop computer)
  • Ability to read and speak English
  • Availability for duration of the study (3-4 weeks)
  • To proceed to oral fluid testing, positive result for urinary TCH-COOH

Who cannot take part

  • Inability/unwillingness to provide contact information; Individuals age 18-35 are invited to screen here: https://redcap.link/softa-bch

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 35 years old?

Where in United States

  • Boston Children's HospitalBoston, United StatesContact: Lydia A. Shrier, MD, MPHTaking people

About the trial

What the trial wants to find out

The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-35 years who have used cannabis at least 1 time per week on average in the past 30 days. Participants will complete oral fluid (saliva) tests, urine tests, and Timeline Follow-back interviews (self-report) that indicate their recent cannabis use (delta-9-THC). Participants will present for 3 virtual study visits across ~ 3-4 weeks and be asked to complete activities in between: Study Visit 1 (Day 0; informed consent, baseline survey, TLFB interview), Study Visit 2 (~ Day 7; TLFB interview, urine testing), 6 days of at-home videorecorded oral fluid testing, Study Visit 3 (~ Day 28; TLFB interview, urine test, oral fluid test, survey, interview).

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Individuals age 18-35 are invited to screen here: https://redcap.link/softa-bch

The group in the trial

  • Prospective community sample

    Community sample of 200 younger adults aged 18-35 years who have used cannabis in the past 30 days at baseline, report use frequency of ≥1x/week at baseline, and have a positive test for urinary 11-nor-9-carboxy-delta-9-tetrocannabinol (THC-COOH) at the Day-7 visit

    Treatment: Biologic testing for THC

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials
Fit questions
Built from NCT06891235, who can take part
Record updated
6 November 2026