Testing How Ultrasound Rock Salt Mist Reaches the Lungs
Tests how a breathed-in salt mist reaches the lungs in adults with lung disease.
Plain-language title generated from the registry record
Registry title: Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- China-Japan Friendship HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jingen Xia
- Trial code
- NCT06891274
- Record updated
- 24 March 2025
- Original description
In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro - moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small - volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations.Read full original descriptionShow less
Study on the Lung Aerosol Deposition of Ultrasonic Rock Salt Inhalation Therapy
In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro - moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small - volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations.
In the clinical phase, the investigators plan to have subjects inhale radioactive aerosols and use PET/CT imaging technology to assess the deposition rate of aerosol particles in the lungs. By quantitatively analyzing the images, the investigators will study their distribution characteristics in real human bodies to verify the accuracy of the in vitro models and the potential for clinical application.
Inclusion: Healthy volunteers; Patients with chronic airway disease requiring nebulization therapy.
Exclusion: Those aged < 18 years; Refusing to participate in the study; Patients requiring invasive ventilator assisted breathing; Patients with artificial airways. Patients with chronic liver and kidney function injury. Allergic to radioactive elements.