Comparing two steroid medicines for flare-ups of chronic lung disease
Compares hydrocortisone with a related steroid in adults over 40 having COPD flare-ups.
Plain-language title generated from the registry record
Registry title: Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Key facts
- Where
- Copenhagen, Frederiksberg, Hellerup, Herlev, Hillerød, Holbæk, Hvidovre, Køge, Næstved, Ringsted, Rønne, Roskilde, and Slagelse, DenmarkSee the 14 sites
- Phase
- Phase 4
Where in Denmark
- Amager HospitalCopenhagen, DenmarkTaking people
- Bispebjerg HospitalCopenhagen, DenmarkTaking people
- Frederiksberg HospitalFrederiksberg, DenmarkTaking people
- Gentofte HospitalHellerup, DenmarkTaking people
- Herlev HospitalHerlev, DenmarkTaking people
- Nordsjællands HospitalHillerød, DenmarkTaking people
- Holbæk SygehusHolbæk, DenmarkTaking people
- Hvidovre HospitalHvidovre, DenmarkTaking people
- University Hospital of Region Zealand, KøgeKøge, DenmarkTaking people
- Næstved SygehusNæstved, DenmarkTaking people
- Ringsted SygehusRingsted, DenmarkTaking people
- Bornholm HospitalRønne, DenmarkTaking people
- University Hospital of Region Zealand, RoskildeRoskilde, DenmarkTaking people
- Slagelse SygehusSlagelse, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen Respiratory Research
- Trial code
- NCT06892210
- Record updated
- 18 March 2026
- Original description
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days.Read full original descriptionShow less
Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days.
Participants will randomized to receive treatment with either hydrocortisone or prednisolone.
Inclusion: Age ≥40 years; Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44.
Exclusion: All diagnoses that would merit treatment with a specific corticosteroid; Active tuberculosis or invasive fungal infection; Pregnant or breastfeeding women.