Studies how anti-seizure medicines affect brain activity in adults with epilepsy
Measures brain responses to magnetic pulses before and after restarting anti-seizure medicines.
Plain-language title generated from the registry record
Registry title: PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Key facts
- Where
- Bern, SwitzerlandSee the site
Where in Switzerland
- University Hospital BernBern, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Insel Gruppe AG, University Hospital Bern
- Trial code
- NCT06892457
- Record updated
- 24 March 2025
- Original description
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are:Read full original descriptionShow less
PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are:
1. Does the magnitude of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) measured with electroencephalography (EEG) change between OFF and ON medication states? 2. Do these changes in TEP amplitude persist over time? Researchers will compare each participant's measurements in the OFF state with those in the ON state to see if TEPs change following ASM (re)start.
Participants will undergo one TMS-EEG session scheduled around their prescribed ASM (re)start and one 1-6 months later.
Inclusion: Adult patients (≥ 18j) with epilepsy receiving a prescription for an anti-seizure medication for clinical reasons; Written informed consent.
Exclusion: Presence of any electrical implants (e.g. neurostimulator or drug delivery system) or any metallic implants anywhere in the head (excluding teeth); Use of any kind of drug or alcohol, nicotine allowed; Uncontrolled psychiatric disorder; Increased intracranial pressure; For female participants: If pregnancy cannot be ruled out with sufficient certainty, a pregnancy test (urine) will be carried out before using TMS; Inability to give consent.