Tests RAY1225 for weight loss in adults with obesity or overweight
Compares RAY1225 with a placebo in adults who have obesity or are overweight.
Plain-language title generated from the registry record
Registry title: Evaluation of RAY1225 in Adult Participants Who Have Obesity or Are Overweight
Key facts
- Where
- Beijing, ChinaSee the site
- Phase
- Phase 3
Where in China
- Peking University People's HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guangdong Raynovent Biotech Co., Ltd
- Trial code
- NCT06893016
- Record updated
- 17 July 2025
- Original description
The primary objective of this study is to demonstrate that RAY1225 is superior to placebo for percent change in body weight.Read full original descriptionShow less
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study Evaluating the Safety, Tolerability, and Efficacy of RAY1225 in Participants Who Have Obesity or Are Overweight
The primary objective of this study is to demonstrate that RAY1225 is superior to placebo for percent change in body weight.
Inclusion: Age ≥ 18 years; Body mass index ≥ 28 kg/m2 or ≥24kg/m² to <28 kg/m2 with at least 1 of the following weight-related comorbidities: a) Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, or the use of at least one antihypertensive medication to maintain normal blood pressure;b) Fasting triglycerides (TG) ≥1.70 mmol/L, fasting low-density lipoprotein cholesterol (LDL-C) ≥4.1 mmol/L, fasting high-density lipoprotein cholesterol (HDL-C) <1.04 mmol/L, or the need for at least one lipid-lowering treatment to maintain normal lipid levels; c) Obstructive sleep apnea syndrome; d) Fatty liver; e) Cardiovascular disease; e) Polycystic ovary syndrome; History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise.
Exclusion: Obesity known to be caused by monogenic mutations, other diseases, or medications; Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2; A history of moderate to severe depression at any time in the past or a score of ≥15 on the PHQ-9 questionnaire at screening; a history of bipolar disorder, schizophrenia, or other severe psychiatric disorders; A history of organ transplantation (excluding corneal transplant), or being currently prepared to undergo organ transplantation; Allergic constitution (allergic to multiple medications or foods), or those known to be allergic to RAY1225, GLP-1 receptor agonists, or GLP-1 related drugs; Plans to quit smoking during the study period.