Orthobiologic Treatment for Knee Osteoarthritis
Key facts
- Where
- Tromsø, NorwaySee the site
- Phase
- Phase 2/3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT06893250, who can take part
Where in Norway
- University Hospital in Northern NorwayTromsø, NorwayNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Hospital of North Norway
- Trial code
- NCT06893250
- Record updated
- 15 June 2026
- Original description
The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are:Read full original descriptionShow less
Orthobiologic Treatment for Knee Osteoarthritis (Ortobiologisk Behandling av Kneleddsartrose)
The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are:
* Will the patients clinically benefit from the treatment, and if so, which treatment is better? * Will there be radiological findings to support this? Participants will be randomized into one of four groups: PRP, ADS, PRP + ADS or placebo treatment (saline) and will be examined and get an X-ray and MRI of the knee taken at inclusion and after 1 and 2 years.
Inclusion: Symptomatic osteoarthritis in the knee grade I-III using the Kellgren-Lawrance Grading Scale; Age 40-70 years; Minimum VAS 3; No use of NSAIDs or steroids the last 14 days; No injections of hyaluronic acid the last three months; Varus/valgus deformity \<5 degrees as evaluated on x-ray imaging.
Exclusion: Previous knee surgery on the affected knee; Previous infection in the knee; Cancer; Other diseases (rheumatoid arthritis, diabetes, systemic diseases or corticosteroid-demaning disease); Patients with a high risk of deep vein thrombosis; Patients who cannot cooperate/are low compliance (psychiatric disease) or has contraindications for MRI; Pregnant or breastfeeding women; Other etiologies of knee pain (refered pain, pain from the back, dislocated meniscus on MRI, osteoarthritis grade IV using the Kellgren-Lawrance Grading Scale); Secondary osteoarthritis in the knee.