NCT06894004Recruiting
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 10 Mar 2025
- Start date
- 24 Feb 2025
- Primary completion date
- 30 Nov 2030
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Familial hypercholesterolaemia
- NCT number
- NCT06894004
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 24 Feb 2025 to the primary completion date, 30 Nov 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- current use of lipid-lowering drugs
- currently on a ketogenic diet and unwilling to change diet
Other illness
- personal or family history of familial hypercholesterolemia
- hypertension
- prediabetes or diabetes
- known atherosclerotic cardiovascular disease
Other
- current tobacco use
- elevated Lp(a) \> 6.5% of ApoB-containing lipoproteins at baseline
- oral contraceptive use
- contraindication to heparin
- unwilling to abstain from alcohol
Who the study is looking for
- age ≥ 18 and \< 40 years
- BMI ≥ 18.5 and \< 25.0 kg/m2
- baseline serum LDL-c \< 150 mg/dL (\< 3.9 mmol/L)
- baseline serum TG \< 100 mg/dL (\< 1.1 mmol/L)
- HbA1c ≤ 5.6%.
Age in the registry: 18 years to 39 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.