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Evaluation of the Efficacy of E2R Hypnotherapy in the Management of Chronic Insomnia in Primary Care (HypERR)

Key facts

Who runs it
Rennes University Hospital
Where
France32 sites in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
136 people, planned
Started
14 Oct 2025
Expected to end
14 Oct 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • "Standard care" control group (without hypnosis)
  • Experimental group: "E2R hypnosis"
Record updated
19 August 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Patient aged 18 or over,
  • Patient suffering from chronic insomnia according to the DSM-5 definition, whether or not treated with psychotropic drugs:; At least one of the following sleep disorders: difficulty in falling asleep, difficulty in maintaining sleep, waking up too early and inability to go back to sleep, and * At least 3 nights a week for at least 3 months, and * In an adequate night-time sleep context, and * With at least one significant impact on, or impairment of, social, occupational or behavioral functioning, and * Insomnia not attributable to the physiological effects of a substance, and * Insomnia not explicable by a medical condition or mental disorder
  • Patient willing to undergo hypnotherapy for 4 sessions of 30 min over 6 weeks,
  • Patient whose treating physician is the investigator,
  • Patient able to give free, informed, written consent,
  • Patient affiliated to the French social security system

Who cannot take part

  • Patients receiving or having received one or more hypnotherapy sessions (for any reason) in the last 5 years prior to inclusion,
  • Patient participating in another study involving the treatment of insomnia or another pathology having an impact on sleep disorders,
  • Patient unable to complete a self-administered questionnaire,
  • Patients with poor or no understanding of the French language,
  • Patients unable to attend hypnotherapy consultations,
  • Deaf or hard-of-hearing patients without hearing aids,
  • Patient under legal protection (safeguard of justice, curatorship, guardianship) or deprived of liberty,
  • Women declaring themselves pregnant or breastfeeding

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

In France, the treatment of chronic insomnia relies mainly on hypnotic drugs in routine care, despite the high level of iatrogenicity. Cognitive-behavioral therapy (CBT) is recommended by the HAS as a non-pharmaceutical first-line therapy for chronic insomnia. Despite evidence of their efficacy in chronic insomnia, these therapies remain underdeveloped in France (few practitioners, time-consuming for the patient). Hypnotherapy is another non-drug intervention suitable for routine outpatient care. Among the hypnosis methods practiced in France, E2R (Emotion, Regression, Repair) is a hypnotherapy method used in general practice, particularly for chronic insomnia. To date, no clinical trials have been carried out to demonstrate its effectiveness in this pathology.

Read full original descriptionShow less

The HypERR study is a multicenter, randomized, open-label study designed to evaluate the efficacy of a hypotherapy method called E2R in the management of chronic insomnia, by comparing it with standard care (without hypnosis).

The 2 groups in the trial

  • Standard careExisting treatment, for comparison

    Patients will receive the usual care offered by their GP, the investigator in the study (except hypnosis).

    Treatment: "Standard care" control group (without hypnosis)

  • E2R hypnosisTreatment being tested

    4 x 30-minute hypnotherapy sessions over 6 weeks by the hypnotherapist using the E2R method (with self-hypnosis)

    Treatment: Experimental group: "E2R hypnosis"

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Evaluation of the Efficacy of E2R Hypnotherapy in the Management of Chronic Insomnia in Primary Care
Record updated
19 August 2026