Tests a brain device that stimulates seizure-related brain areas in drug-resistant epilepsy
Tests a brain device that stimulates areas linked to seizures in epilepsy.
Plain-language title generated from the registry record
Registry title: Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Key facts
- Where
- Houston and Rochester, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 3 and 70 years old?
Source: NCT06898138, who can take part
Where in United States
- Baylor College of MedicineHouston, United StatesNo longer taking part
- Mayo ClinicRochester, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06898138
- Record updated
- 11 August 2026
- Original description
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.Read full original descriptionShow less
Acute Stimulation for the Modulation of Epileptic Events With a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.
Inclusion: Patients with medically refractory epilepsy, who have been deemed appropriate candidates for intracranial EEG monitoring; Adult men and women (18≤ age <70 years); Children (3≤ age <18 years); Includes women and minorities.
Exclusion: Subjects will be excluded if their condition makes them unable to continue with recordings.