Short Radiotherapy Course Before Surgery for Soft Tissue Sarcoma
Tests a 5-day radiation course before surgery in adults with soft tissue sarcoma.
Plain-language title generated from the registry record
Registry title: Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma
Key facts
- Where
- Charleston, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Medical University of South CarolinaCharleston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of South Carolina
- Trial code
- NCT06905132
- Record updated
- 30 March 2026
- Original description
The purpose of this research study is to preserve healthy tissue around the cancer on the arm(s) and/or leg(s) using Hypofractionated radiotherapy, while treating the cancer and preventing it from spreading to other areas of the body.Read full original descriptionShow less
Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma: A Single Institution Phase II Trial
The purpose of this research study is to preserve healthy tissue around the cancer on the arm(s) and/or leg(s) using Hypofractionated radiotherapy, while treating the cancer and preventing it from spreading to other areas of the body.
Inclusion: Willingness and provision of informed consent via signed and dated copy; Histologically confirmed STS of extremity or trunk; Male or female, aged greater than or equal to 18 years old; ECOG performance status 0-3; Meets screening criteria for receipt of radiotherapy; Deemed eligible for wide local excision; Patient and/or physician identified possible barriers to receiving a 5-week course of conventionally fractionated preoperative radiotherapy. Potential barriers include but are not limited to concern for local progression that could precluded or complicate limb sparing surgery, concern for distant progression that could result in patient being non-operative, financial and/or physical burden of travel for daily treatments, financial burden of time away from work or caregiving.
Exclusion: Prior radiation therapy in the proposed treatment area; Women who are pregnant or plan to become pregnant during the period of radiation therapy; Planned concurrent administration of chemotherapy and radiation therapy; Distant metastatic disease; Simultaneous treatment of another malignancy.