Testing when flu vaccine is given in people with chronic kidney failure
Tests timing of flu vaccine and immune response in adults with chronic kidney disease.
Key facts
- Who runs it
- Centre Hospitalier Universitaire de Nice
- Where
- Nice, FranceSee the site
- Trial code
- Registry title
- Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure
- Status
- Recruiting
- People taking part
- 735 people, planned
- Started
- 3 Sept 2025
- Expected to end
- Sept 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Vaccine injection
- Record updated
- 15 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with severe chronic kidney failure, people on dialysis, or people with a kidney transplant, who are due to get a flu vaccine.
- Age
- 18 to 100 years
- Sex
- All sexes
- Disease stage
- Chronic kidney failure at stage 4 or 5 (estimated GFR < 30mL/min/1.73m2), or on dialysis, or a kidney transplant at any GFR.
- Earlier treatment
- Must not have had a flu vaccine yet this season. No treatment for rejection in the last 3 months. No kidney transplant with induction in the last 6 months. No immunoglobulin infusion in the last 3 months.
Main reasons for not taking part
- Known allergy to flu vaccine or egg proteins
- Flu vaccine already given this season
- Current infection or acute illness
- Immunosuppressive treatment such as CTLA4 agonist, complement inhibitor or anti-CD20
- Not covered by Social Security, or cannot speak French
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Chronic renal failure patient at stage 4 or 5 (i.e. estimated GFR < 30mL/min/1.73m2); or Dialysis patient; or renal transplant patient regardless of GFR
- Age ≥ 18 years
- Indication for influenza vaccination
- Express free and informed consent
Who cannot take part
- Previous influenza vaccination for the current season
- Treatments with a major impact on vaccine response:
- Treatment of rejection within the previous 3 months
- Renal transplantation with induction performed within the previous 6 months
- Immunosuppressive treatment including CTLA4 agonist, complement inhibitor, anti-CD20
- Known hypersensitivity to influenza vaccine or egg proteins
- Current infection
- Current acute illness
- Treatments that may distort the serological response: Polyvalent immunoglobulin infusion within the preceding 3 months
- Vulnerable persons (minors, adults under guardianship or trusteeship, persons deprived of their liberty, persons unable to speak French)
- Subjects not affiliated to Social Security
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Where in France
- CHU Nice - Hôpital Pasteur 2Nice, FranceContact: Clément GOSSET, MDTaking people
About the trial
What the trial wants to find out
Immune response to influenza vaccine in patients with chronic renal insufficiency.
The 2 groups in the trial
- Morning injectionExisting treatment, for comparison
VAXIGRIPTETRA influenza vaccine injection between 07:00 am and 11:00 am.
Treatment: Vaccine injection
- Evening injectionExisting treatment, for comparison
VAXIGRIPTETRA influenza vaccine injection between 05:00 pm and 09:00 pm.
Treatment: Vaccine injection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure - CHRONOVAX 2
- Plain-language title
- Testing when flu vaccine is given in people with chronic kidney failureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06907667, who can take part
- Record updated
- 15 May 2026