Comparing Two Stimulation Methods for Parkinson's Disease Using Brain Implants
Compares adaptive and continuous deep brain stimulation in adults with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Key facts
- Where
- Leuven, BelgiumSee the site
Where in Belgium
- UZ LeuvenLeuven, BelgiumNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Trial code
- NCT06909045
- Record updated
- 29 January 2026
- Original description
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease. The main question it aims to answer is:Read full original descriptionShow less
Randomized Controlled Trial Comparing Adaptive Versus Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease. The main question it aims to answer is:
- whether the change in daily mean ON time without troublesome dyskinesia in aDBS is greater than cDBS over a six-month follow-up period?
Researchers will compare aDBS to regular continue deep brain stimulation (cDBS).
Participants will:
* be set up to cDBS during the first programming visit (visit 2); * be randomized 1:1 to aDBS or cDBS two weeks after visit 2; * follow-up will be at three and six months after visit 2; * complete PD Home diary at baseline, two weeks, three months and at six months after visit 2.
Inclusion: Diagnosis of idiopathic PD based on the UK Brain Bank criteria (Hughes et al. 1992); Age older than 18 years; Previous implantation of Medtronic PerceptTM PC/RC DBS electrodes bilateral targeting the STN; Optimal contact point compatible with aDBS in at least one STN; Reliable beta peak in at least one STN; Able to provide informed consent and comply with the study protocol; Understand the Dutch language.
Exclusion: Mild cognitive impairment or dementia; Legally incompetent adults; Patients with ongoing participation in other clinical trials involving neurological interventions; Inability to recognize the difference between the motor ON or OFF state; Pregnancy.