Taking people in United StatesPhase 4
Inclisiran Compared With Placebo After Heart or Leg Artery Procedures
Tests inclisiran injection against placebo in adults having heart or leg artery procedures.
Plain-language title generated from the registry record
Registry title: Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
Key facts
- Where
- Albany, Albuquerque, Alexander City, Amarillo, Anderson, Asheville, Aurora, Austin, Avondale, Bangor, Bethlehem, Beverly Hills, Birmingham, Bossier City, Bridgeport, Bridgewater, Buffalo, Camp Hill, Canton, Chambersburg, Charlotte, Chicago, Chula Vista, Clearwater, Clinton, Columbia, Concord, Conroe, Coral Gables, Covina, Covington, Danbury, Daytona Beach, Duluth, Elkhart, Elmer, Englewood, Fayetteville, Flemington, Gainesville, Germantown, Glendora, Grand Island, Green Bay, Greeneville, Greensboro, Haddon Heights, High Point, Houston, Humble, Huntsville, Jackson, Jacksonville, Jonesboro, Kingwood, Lancaster, Lanham, Lansing, Largo, Lebanon, Lincoln, Little Rock, Lufkin, Mankato, McAllen, Merrillville, Miami Lakes, Midland, Milwaukee, Morrisville, Murray, Nashville, New Orleans, New York, Newport Beach, Newport News, Norfolk, Northridge, Oklahoma City, Omaha, Overland Park, Owensboro, Panama City, Park Ridge, Peachtree City, Peoria, Pomona, Pontiac, Port Charlotte, Poughkeepsie, Puyallup, Raleigh, Rapid City, Richmond, Riverside, Rochester, Rochester Hills, Rockford, Rockville, Round Rock, Safety Harbor, Salisbury, San Diego, San Francisco, San Marcos, Sewell, Shreveport, Silver Spring, Southaven, Springfield, Stamford, Staten Island, Tacoma, Takoma Park, Tampa, The Bronx, Thornton, Toledo, Tomball, Torrance, Tucker, Tupelo, Van Nuys, Ventura, West Des Moines, West Hills, West Monroe, West Reading, Wichita, Winchester, Winston-Salem, York, and Zanesville, United StatesSee the 149 sites
- Phase
- Phase 4
Where in United States
- Capital Cardiology AssociatesAlbany, United StatesTaking people
- Presbyterian Heart GroupAlbuquerque, United StatesTaking people
- Advanced Cardiovascular, LLCAlexander City, United StatesTaking people
- Amarillo Heart Clinical Research Institute, Inc.Amarillo, United StatesTaking people
- PharmaTex ResearchAmarillo, United StatesTaking people
- AnMed Health Medical CenterAnderson, United StatesTaking people
- Asheville Cardiology Associates Research DepartmentAsheville, United StatesTaking people
- University of Colorado Anschutz Medical CampusAurora, United StatesTaking people
- Austin HeartAustin, United StatesTaking people
- IMS CardiologyAvondale, United StatesTaking people
- Northern Light Eastern Maine Medical CenterBangor, United StatesTaking people
- St. Luke's University Health NetworkBethlehem, United StatesTaking people
- Pacific Oaks Medical GroupBeverly Hills, United StatesTaking people
- Cardiology, PCBirmingham, United StatesTaking people
- Grace Research LLCBossier City, United StatesTaking people
- Bridgeport HospitalBridgeport, United StatesTaking people
- Advanced Heart Care LLCBridgewater, United StatesTaking people
- Sisters of Charity HospitalBuffalo, United StatesTaking people
- Trinity Medical WNY, PCBuffalo, United StatesTaking people
- Capital Area Research, LLCCamp Hill, United StatesTaking people
- Aultman HospitalCanton, United StatesTaking people
- Wellspan Chambersburg HospitalChambersburg, United StatesTaking people
- Mecklenburg Heart SpecialistsCharlotte, United StatesTaking people
- Novant Health Clinical Research/Heart & Vascular InstituteCharlotte, United StatesTaking people
- University of Illinois ChicagoChicago, United StatesTaking people
- Cardiovascular Institute of San DiegoChula Vista, United StatesTaking people
- Baycare Medical GroupClearwater, United StatesTaking people
- Clearwater Cardiovascular ConsultantsClearwater, United StatesTaking people
- Medstar Southern Maryland Hospital CenterClinton, United StatesTaking people
- University of Missouri Health CareColumbia, United StatesTaking people
- John Muir Medical Center-Concord CampusConcord, United StatesTaking people
- Javara inc.Conroe, United StatesNo longer taking part
- Pioneer Clinical StudiesCoral Gables, United StatesTaking people
- Valley Clinical TrialsCovina, United StatesNo longer taking part
- Louisiana Heart CenterCovington, United StatesTaking people
- Nuvance Health-Danbury HospitalDanbury, United StatesTaking people
- Arrow Clinical TrailsDaytona Beach, United StatesTaking people
- Cardiology Research AssociatesDaytona Beach, United StatesTaking people
- Aspirus Saint Luke's HospitalDuluth, United StatesTaking people
- Essentia Health-SMMCDuluth, United StatesTaking people
- Midwest Cardiovascular Research and Education FoundationElkhart, United StatesTaking people
- Cardiovascular Associates of the Delaware ValleyElmer, United StatesTaking people
- Aurora Denver Cardiology Associates - EnglewoodEnglewood, United StatesTaking people
- Javara Inc.Fayetteville, United StatesTaking people
- Advanced Heart and Vascular Institute of HunterdonFlemington, United StatesTaking people
- Northeast Georgia Heart Center, PCGainesville, United StatesTaking people
- Stern Cardiovascular CenterGermantown, United StatesTaking people
- Thrive Clinical Research GroupGlendora, United StatesTaking people
- CHI Health Nebraska HeartGrand Island, United StatesTaking people
- Bellin Memorial HospitalGreen Bay, United StatesTaking people
- Ballad Health SystemGreeneville, United StatesTaking people
- Moses H Cone Memorial HospitalGreensboro, United StatesTaking people
- Cardiovascular Associates of the Delaware ValleyHaddon Heights, United StatesTaking people
- Wake Forest University Health SciencesHigh Point, United StatesTaking people
- Texas Heart InstituteHouston, United StatesTaking people
- Vital Heart and VeinHumble, United StatesTaking people
- Heart Center Research, LLCHuntsville, United StatesTaking people
- Apex Research Foundation, LLCJackson, United StatesTaking people
- The Jackson Clinic, PAJackson, United StatesTaking people
- First Coast Cardiovascular Institute PAJacksonville, United StatesTaking people
- UF Health JacksonvilleJacksonville, United StatesTaking people
- Cardiology Associates Research GroupJonesboro, United StatesTaking people
- Texas Cardiology Associates of HoustonKingwood, United StatesTaking people
- Penn Lancaster General Health Research InstituteLancaster, United StatesTaking people
- Capitol Cardiology Associates PALanham, United StatesTaking people
- McLaren Center for Research and InnovationLansing, United StatesTaking people
- UMH-Sparrow Clinical Research InstituteLansing, United StatesTaking people
- Clearwater Cardiovascular and Interventional Consultants- BardmoorLargo, United StatesTaking people
- Dartmouth Hitchcock Medical CenterLebanon, United StatesTaking people
- Bryan HeartLincoln, United StatesTaking people
- CHI Health Nebraska HeartLincoln, United StatesTaking people
- Arkansas CardiologyLittle Rock, United StatesTaking people
- Arkansas Heart HospitalLittle Rock, United StatesTaking people
- Heart Institute of East TexasLufkin, United StatesTaking people
- JAVARA Inc, - Mankato ClinicMankato, United StatesTaking people
- DHR Health Institute for ResearchMcAllen, United StatesTaking people
- Heart Center of Lake CountyMerrillville, United StatesTaking people
- Inpatient Research Clinic LLCMiami Lakes, United StatesTaking people
- MyMichigan Medical Center MidlandMidland, United StatesTaking people
- Aurora Saint Luke's Medical CenterMilwaukee, United StatesTaking people
- Duke CardiologyMorrisville, United StatesTaking people
- Intermountain Medical CenterMurray, United StatesTaking people
- TriStar Centennial Medical centerNashville, United StatesTaking people
- Tulane School of MedicineNew Orleans, United StatesTaking people
- Mount Sinai School of MedicineNew York, United StatesTaking people
- Radin Cardiovascular Medical Group, IncNewport Beach, United StatesTaking people
- TPMG Clinical ResearchNewport News, United StatesTaking people
- Sentara Norfolk General HospitalNorfolk, United StatesTaking people
- Amicis ResearchNorthridge, United StatesTaking people
- Valley Clinical Trials, LLC - Flourish ResearchNorthridge, United StatesTaking people
- South Oklahoma Heart Research LLCOklahoma City, United StatesTaking people
- Methodist Physicians Clinic Heart ConsultantsOmaha, United StatesTaking people
- Midwest Heart and Vascular SpecialistsOverland Park, United StatesTaking people
- Research Integrity LLCOwensboro, United StatesTaking people
- Cardiovascular Institute of Northwest FloridaPanama City, United StatesTaking people
- Gulf Coast Heart and VascularPanama City, United StatesTaking people
- Advocate Aurora Lutheran General HospitalPark Ridge, United StatesTaking people
- Javara, Inc.Peachtree City, United StatesNo longer taking part
- OSF Multi-Specialty GroupPeoria, United StatesTaking people
- AtlantiCare Regional Medical CenterPomona, United StatesTaking people
- Trinity Health Oakland HospitalPontiac, United StatesTaking people
- Charlotte Heart & Vascular Center, PAPort Charlotte, United StatesTaking people
- Hudson Valley Cardiovascular Practice PCPoughkeepsie, United StatesTaking people
- MultiCare Institute for Research and InnovationPuyallup, United StatesTaking people
- Duke Vascular Surgery and Vein Center at Brier CreekRaleigh, United StatesTaking people
- Monument Health Clinical ResearchRapid City, United StatesTaking people
- Chippenham HospitalRichmond, United StatesTaking people
- Reid Physician AssociatesRichmond, United StatesTaking people
- Riverside Community HospitalRiverside, United StatesTaking people
- University of Rochester Medical CenterRochester, United StatesTaking people
- Healthy Heart Cardiology at Rochester Hills (Advanced Cardiology AssociatesRochester Hills, United StatesTaking people
- OSF HealthCare Cardiovascular InstituteRockford, United StatesTaking people
- Shady Grove Adventist HospitalRockville, United StatesTaking people
- Austin Heart PLLCRound Rock, United StatesTaking people
- Clearwater Cardiovascular ConsultantsSafety Harbor, United StatesNo longer taking part
- TidalHealth Peninsula RegionalSalisbury, United StatesTaking people
- Kaiser Permanente - San DiegoSan Diego, United StatesTaking people
- San Diego Cardiac CenterSan Diego, United StatesTaking people
- Sutter Health Heart and VascularSan Francisco, United StatesTaking people
- Austin HeartSan Marcos, United StatesTaking people
- Cardiovascular Associates of the Delaware ValleySewell, United StatesTaking people
- Cardiovascular Solutions LLCShreveport, United StatesTaking people
- Jadestone Clinical Research, LLCSilver Spring, United StatesTaking people
- Stern CardiovascularSouthaven, United StatesTaking people
- Heart House Research Foundation LLCSpringfield, United StatesTaking people
- Cardiology Associates of Fairfield CountyStamford, United StatesTaking people
- Richmond University Medical CenterStaten Island, United StatesTaking people
- MultiCare Institute for Research and InnovationTacoma, United StatesTaking people
- Washington Vascular Specialists - ClinRe 001-136Takoma Park, United StatesTaking people
- Tampa Cardiovascular Interventions and ResearchTampa, United StatesTaking people
- Jacobi Medical CenterThe Bronx, United StatesTaking people
- ClinRe 001-001Thornton, United StatesTaking people
- ProMedica Toledo HospitalToledo, United StatesTaking people
- Northwest Houston Heart CenterTomball, United StatesTaking people
- Viva Heart and VeinTomball, United StatesTaking people
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterTorrance, United StatesTaking people
- Atlanta Heart Specialists LLCTucker, United StatesTaking people
- Cardiology Associates of North MississippiTupelo, United StatesTaking people
- The Heart Medical GroupVan Nuys, United StatesTaking people
- FOMAT - West Coast Research CenterVentura, United StatesTaking people
- Iowa Heart CenterWest Des Moines, United StatesTaking people
- Interventional Cardiology Medical GroupWest Hills, United StatesTaking people
- Monroe Research, LLCWest Monroe, United StatesTaking people
- Cardiology Associates of West ReadingWest Reading, United StatesTaking people
- Kansas Nephrology Physicians, PAWichita, United StatesTaking people
- Winchester Cardiology and Vascular MedicineWinchester, United StatesTaking people
- Novant Health Forsyth Medical CenterWinston-Salem, United StatesTaking people
- WellSpan Heart and Vascular ResearchYork, United StatesTaking people
- Genesis HealthCare SystemZanesville, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Duke University
- Trial code
- NCT06909565
- Record updated
- 29 October 2026
- Original description
V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization. Inclisiran is a subcutaneous, twice-yearly injection that is FDA-approved as an adjunct with statin therapy and on the market to lower LDL-C in high-risk populations.Read full original descriptionShow less
Evaluation of Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention (V-INTERVENTION)
V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization. Inclisiran is a subcutaneous, twice-yearly injection that is FDA-approved as an adjunct with statin therapy and on the market to lower LDL-C in high-risk populations.
Inclusion: Signed informed consent must be obtained prior to participation in the study; Males or females ≥ 18 years of age; Within 14 days of a successful percutaneous coronary intervention (PCI) or peripheral endovascular intervention (PVI) for symptomatic CAD or lower extremity PAD; Patients undergoing planned staged interventions are eligible for randomization only after the last planned intervention.
Exclusion: Current or planned use of an open-label PCSK9 inhibitor during the study; Any prior treatment with inclisiran; Active or planned participation in another clinical study involving investigational drugs or devices during the study; Patients taking prohibited therapies as listed in Section 6.6.3; Any serious liver disease, metabolic disease, neoplasm, end-stage kidney disease, or other condition in the opinion of the investigator that would inhibit trial participation or confound trial results; Planned future PCI or PVI; Any other reason why, in the opinion of the investigator, the participant would not be suitable for study participation including safety considerations and the ability to adhere to protocol activities; Pregnant or breast-feeding women.