Tests time-restricted eating and calorie restriction in prediabetic adults with obesity
Tests time-restricted eating and calorie cutting in obese adults with prediabetes.
Plain-language title generated from the registry record
Registry title: The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old
Key facts
- Where
- Amman, JordanSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 40 with obesity and insulin resistance who are not very active. It tests eating within set hours and cutting calories.
- Age
- 18 to 40 years
- Sex
- Women and men can join.
- Disease stage
- Insulin resistance diagnosed by a doctor (by HOMA-IR score), with a BMI from 30 to 39.9 kg/m2.
- Earlier treatment
- Weight must have been stable for 3 months before the study. People who had weight loss surgery cannot join.
- Biomarker or test result
- A HOMA-IR score that shows insulin resistance.
Main reasons for not taking part
- Previous weight loss surgery
- Pregnancy or plan to become pregnant, or breastfeeding
- Chronic diseases
- Drugs that could affect the diet, such as corticosteroids and anti-diabetic drugs
- Type 1 or type 2 diabetes
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT06911918, who can take part
Where in Jordan
- Najd Nutri CenterAmman, JordanContact: Najd Abdullah Sarayreh, PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Jordan
- Trial code
- NCT06911918
- Record updated
- 4 April 2025
- Original description
Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature. This studyl investigates the effects of time-restricted eating (TRE) with calorie restriction (CR), TRE without CR, and CR without TRE on glycemic control and pro-inflammatory biomarkers among prediabetic obese Jordanian adults aged 18-40 years. The study assesses changes in pro-inflammatory biomarkers (IL-1β, TNF-α, IL-6), insulin resistance (HOMA-IR), and body composition over 12 weeks.Read full original descriptionShow less
The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old: A Randomized Control Study
Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature. This studyl investigates the effects of time-restricted eating (TRE) with calorie restriction (CR), TRE without CR, and CR without TRE on glycemic control and pro-inflammatory biomarkers among prediabetic obese Jordanian adults aged 18-40 years. The study assesses changes in pro-inflammatory biomarkers (IL-1β, TNF-α, IL-6), insulin resistance (HOMA-IR), and body composition over 12 weeks.
Participants (n=120) will be randomized into four intervention arms: (1) TRE with CR, (2) TRE without CR, (3) CR without TRE, and (4) a control group with no dietary restrictions and no TRE. Biweekly anthropometric assessments will evaluate pro-inflammatory biomarkers and biochemical measures at baseline and the end of the study. The findings will provide insights into the comparative effectiveness of TRE and CR, potentially offering a safe, cost-effective intervention to prevent obesity-induced inflammation, prediabetes, and progression to type 2 diabetes mellitus.
Inclusion: IR individuals diagnosed with IR by the physicians as indicated by HOMA-IR score; female and male, BMI ≥ 30 to 39.9 kg/m2; age between 18 and 40 years; stable weight for 3 months before the beginning of the study; sedentary lifestyle.
Exclusion: previous weight loss surgery; drug therapies that could interfere with the effectiveness of the dietary intervention (e.g., use of corticosteroids, and anti-diabetic drugs); chronic diseases; pregnancy or intent to become pregnant; breastfeeding; diabetic type 1 and 2 individuals; anyone physically active to reduce the influence of confounding covariates.