Under construction – not a live service
Sign in
Taking peopleNo phase

Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy

Key facts

Who runs it
Bengu Turemenogullari
Where
Türkiye1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
66 people, planned
Started
15 Apr 2025
Expected to end
31 Dec 2026
Type of study
Interventional, 3 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • 2-point Radiofrequency Ablation
  • 3-point Radiofrequency Ablation
  • 5-point Radiofrequency Ablation
Record updated
9 April 2025

Who can take part

Age
30 years to 75 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • Age between 30-75
  • Chronic knee pain that lasts at least 6 months
  • Radiographic confirmation of osteoarthritis: Presence of Grade 3 or 4 radiographic changes characterized by significant narrowing in the medial space of the tibiofemoral joint according to the Kellgren-Lawrence classification system
  • Knee pain >40 mm when performing one of the two movements that cause the most severe pain (sitting to standing or going up and down stairs) according to 100 mm VAS; 50% reduction in VAS with diagnostic genicular nerve block

Who cannot take part

  • Previous RFA treatment to the knee or hyaluronic acid or steroid injection to the knee within the last 3 months
  • History of previous knee surgery
  • Presence of systemic inflammatory disease such as rheumatoid arthritis
  • Having undergone physical therapy to the knee in the last 6 months or a history of knee trauma
  • Presence of uncontrolled serious illness (cancer, diabetes, etc.), infection, psychiatric disorder, coagulation disorder
  • Clinically significant structural abnormalities other than osteoarthritis that may lead to chronic knee pain
  • Application of other pain treatments
  • Body-Mass İndex <18 and >40 kg/m2
  • Pregnancy

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 30 and 75 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic. Current conservative treatments have moderate effects on chronic knee pain and their use is limited due to the risk of side effects. In addition to pain, patients also experience other symptoms.

Read full original descriptionShow less

As a result of the osteoarthritis process, prorioception in the knee is impaired with a decrease in mechanoreceptors, resulting in loss of balance and an increase in the risk of falling.

The 3 groups in the trial

  • Radiofrequency Ablation Targeting Two Genicular NervesExisting treatment, for comparison

    2 nerve radiofrequency ablation: Superior Medial (SM) and Inferior Medial (IM) branches. A group of patients will receive a single treatment session using the Radiofrequency Ablation method for 2 nerves, Superior Medial (SM) and Inferior Medial (IM).

    Treatment: 2-point Radiofrequency Ablation

  • Radiofrequency Ablation Targeting Three Genicular NervesExisting treatment, for comparison

    3 nerve radiofrequency ablation: Superior Medial (SM), Superıor Lateral (SL) and Inferior Medial (IM) branches. A group of patients will receive a single treatment session using the Radiofrequency Ablation method for 3 nerves, Superior Medial (SM), Superior Lateral (SL) and Inferior Medial (IM).

    Treatment: 3-point Radiofrequency Ablation

  • Radiofrequency Ablation Targeting Five Genicular NervesExisting treatment, for comparison

    5 nerve radiofrequency ablation: Superior Medial (SM), Superıor Lateral (SL), Inferior Medial(IM), Rekurren Fibular Nerve (RFN) and İnfrapatellar Branch of Saphenous Nerve (IPBSN). Another group of patients will receive a single treatment session with Radiofrequency Ablation for 5 nerves: Superior Medial (SM), Superior Lateral (SL), Inferior Medial (IM), Recurrent Fibular Nerve (RFN) and Infrapatellar Branch of Saphenous Nerve (IPBSN).

    Treatment: 5-point Radiofrequency Ablation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy: Effectiveness of 5 Nerve Protocols Versus 3 Nerve and 2 Nerve Protocols - A Prospective Randomized Controlled Study
Fit questions
Built from NCT06914960, who can take part
Record updated
9 April 2025