Vitamin E Tested for Inflammation in Rheumatoid Arthritis
Tests vitamin E against a placebo in adults with rheumatoid arthritis.
Plain-language title generated from the registry record
Registry title: "Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis"
Key facts
- Where
- Guadalajara, MexicoSee the 2 sites
- Phase
- Phase 2/3
Where in Mexico
- Civil Hospital of GuadalajaraGuadalajara, MexicoTaking people
- Universidad de GuadalajaraGuadalajara, MexicoNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Guadalajara
- Trial code
- NCT06915701
- Record updated
- 13 February 2026
- Original description
The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are:Read full original descriptionShow less
"Evaluation of the Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis"
The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are:
* Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA?
Researchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis.
Participants will:
* Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month. * Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests. * Keep a diary to record your symptoms and how often you take α-tocopherol or placebo.
Inclusion: Female sex; RA classification (ACR/EULAR 2010); Early RA 2 years; Treatment with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations); DAS28 ≥3.2; Vitamin E intake deficiency (<15mg/day); No comorbidities; Age > 18 years; Voluntary participation and informed consent.
Exclusion: Consumption of supplements (iron, vitamin E, and K), and medications such as acetylsalicylic acid, amlodipine, estrogen, glucocorticoids and drugs used to treat dyslipidemias in the last three months; Elimination Criteria:; Liver and kidney disease; Overlap syndrome; Coagulation disorders; Pregnancy; Errors in administration of the 20% supplement; Adverse effects of the supplement; Pregnancy during the study; Insufficient blood sample; Voluntary withdrawal of informed consent.