Tests capsinoid supplement effects on fat-burning tissue in obese teens
Tests a capsinoid supplement with diet in obese adolescents, compared with placebo.
Plain-language title generated from the registry record
Registry title: Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents
Key facts
- Where
- Palavas-les-Flots, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 11 and 18 years old?
Source: NCT06916208, who can take part
Where in France
- Institut Saint PierrePalavas-les-Flots, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Avignon
- Trial code
- NCT06916208
- Record updated
- 30 April 2026
- Original description
Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.Read full original descriptionShow less
Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents
Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.
In addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of "adrenergic" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and/or chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation.
The BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported.
The main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents.
Our general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.
Inclusion: member or beneficiary of a health insurance scheme; aged between 11 and 18; Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months; effective contraception (in pubescent females).
Exclusion: participation in another study or in a period of exclusion determined by a previous study; known allergy to capsinoids and/or soya; inflammatory digestive pathology and/or history of digestive tract surgery; pregnant, parturient or breastfeeding; The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively; It proves impossible to provide the adolescent or parental guardian(s) with informed information.